Microwave-Triggered Smart Drug Release from Liposomes Co-encapsulating   Doxorubicin and Salt for Local Combined Hyperthermia and Chemotherapy of   Cancer

doi:10.1021/acs.bioconjchem.6b00603

CORC > 北京大学 > 工学院

	Microwave-Triggered Smart Drug Release from Liposomes Co-encapsulating Doxorubicin and Salt for Local Combined Hyperthermia and Chemotherapy of Cancer
	Jin, Yushen ; Liang, Xiaolong ; An, Yunkun ; Dai, Zhifei
刊名	BIOCONJUGATE CHEMISTRY
	2016
关键词	TEMPERATURE-SENSITIVE LIPOSOMES INTENSITY FOCUSED ULTRASOUND PHOTOTHERMAL THERAPY DELIVERY SYSTEMS TUMOR ABLATION NANOPARTICLES RESISTANCE MECHANISM GENE NANOCARRIERS
DOI	10.1021/acs.bioconjchem.6b00603
英文摘要	The microwave and temperature sensitive liposomes were fabricated successfully from 1,2-dipalmityol-sn-glycero-3-phosphocholine (DPPC), cholesterol, and 1,2-distearoyl-sn-glycero-3phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000 (DSPE-PEG(2000)) with a molar ratio of 4:1:0.26 by co-encapsulating NaCl and doxorubicin (DOX) through the thin-film hydration method to externally manipulate drug release at a predetermined location in the body at a desired time in the right dosage for combination microwave hyperthermia and chemotherapy of cancer to afford a synergistic therapeutic effect. It was found that the confinement of the high concentration of NaCl ions inside the small size of the liposomes led to a more-rapid temperature elevation than the dissociative ions upon microwave treatment. More than 67.6% doxorubicin was released from the DOX and NaCl co-loaded liposomes (DOX&NaCl@liposomes) upon microwave irradiation for 2 min. After incubation with 2 mg/mL DOX&NaCl@liposomes for 4 h followed by treatment with microwave for 2 min, the inhibition rate of human breast cancer cell MDA-MB-231 was evaluated as 76.1%, much higher than that for NaCl@liposomes (29.8%) and DOX@liposomes (40.2%). The tumor growth inhibition was evaluated to be 73.4% after intravenous injection of DOX&NaCl@liposomes followed by microwave irradiation, much higher than that with only NaCl@liposomes (41.5%) or DOX@liposomes (45.5%) combined with microwave irradiation. Therefore, DOX&NaCl@liposomes could serve as a promising thermochemotherapy nanomedicine for cancer treatment because of its excellent microwave susceptible property and good biocompatibility.; National Key Research and Development Program of China [2016YFA0201400]; State Key Program of National Natural Science of China [81230036]; National Natural Science Foundation for Distinguished Young Scholars [81225011]; National Natural Science Foundation of China [21273014]; Foundation for Innovative Research Groups of the National Natural Science Foundation of China [81421004]; SCI(E); ARTICLE; zhifei.dai@pku.edu.cn; 12; 2931-2942; 27
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/458224]
专题	工学院
推荐引用方式 GB/T 7714	Jin, Yushen,Liang, Xiaolong,An, Yunkun,et al. Microwave-Triggered Smart Drug Release from Liposomes Co-encapsulating Doxorubicin and Salt for Local Combined Hyperthermia and Chemotherapy of Cancer[J]. BIOCONJUGATE CHEMISTRY,2016.
APA	Jin, Yushen,Liang, Xiaolong,An, Yunkun,&Dai, Zhifei.(2016).Microwave-Triggered Smart Drug Release from Liposomes Co-encapsulating Doxorubicin and Salt for Local Combined Hyperthermia and Chemotherapy of Cancer.BIOCONJUGATE CHEMISTRY.
MLA	Jin, Yushen,et al."Microwave-Triggered Smart Drug Release from Liposomes Co-encapsulating Doxorubicin and Salt for Local Combined Hyperthermia and Chemotherapy of Cancer".BIOCONJUGATE CHEMISTRY (2016).