Near-infrared dye-loaded magnetic nanoparticles as photoacoustic contrast agent for enhanced tumor imaging

doi:10.20892/j.issn.2095-3941.2016.0048

CORC > 北京大学 > 工学院

	Near-infrared dye-loaded magnetic nanoparticles as photoacoustic contrast agent for enhanced tumor imaging
	Chuang Gao ; Zi-Jian Deng ; Dong Peng ; Yu-Shen Jin ; Yan Ma ; Yan-Yan Li ; Yu-Kun Zhu ; Jian-Zhong Xi ; Jie Tian ; Zhi-Fei Dai ; Chang-Hui Li ; Xiao-Long Liang
刊名	癌症生物学与医学（英文版）
	2016
关键词	Indocyanine green magnetic nanoparticles photoacoustic tomography tumor imaging Indocyanine green magnetic nanoparticles photoacoustic tomography tumor imaging
DOI	10.20892/j.issn.2095-3941.2016.0048
英文摘要	Objective: Photoacoustic (PA) tomography (PAT) has attracted extensive interest because of its optical absorption contrast and ultrasonic detection. This study aims to develop a biocompatible and biodegradable PA contrast agent particularly promising for clinical applications in human body. Methods: In this study, we presented a PA contrast agent: 1, 2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy (polyethylene glycol)] (DSPE-PEG)-coated superparamagnetic iron oxide (SPIO) nanoparticles (NPs) loaded with indocyanine green (ICG). We used ICG and SPIO NPs because both drugs are approved by the U.S. Food and Drug Administration. Given the strong absorption of near-infrared laser pulses, SPIO@DSPE-PEG/ICG NPs with a uniform diameter of ~28 nm could significantly enhance PA signals. Results: We demonstrated the contrast enhancement of these NPs in phantom and animal experiments, in which thein vivo circulation time of SPIO@DSPE-PEG/ICG NPs was considerably longer than that of free ICG. These novel NPs also displayed a high efficiency of tumor targeting. Conclusions: SPIO@DSPE-PEG/ICG NPs are promising PAT contrast agents for clinical applications.; Objective: Photoacoustic (PA) tomography (PAT) has attracted extensive interest because of its optical absorption contrast and ultrasonic detection. This study aims to develop a biocompatible and biodegradable PA contrast agent particularly promising for clinical applications in human body. Methods: In this study, we presented a PA contrast agent: 1, 2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy (polyethylene glycol)] (DSPE-PEG)-coated superparamagnetic iron oxide (SPIO) nanoparticles (NPs) loaded with indocyanine green (ICG). We used ICG and SPIO NPs because both drugs are approved by the U.S. Food and Drug Administration. Given the strong absorption of near-infrared laser pulses, SPIO@DSPE-PEG/ICG NPs with a uniform diameter of ~28 nm could significantly enhance PA signals. Results: We demonstrated the contrast enhancement of these NPs in phantom and animal experiments, in which thein vivo circulation time of SPIO@DSPE-PEG/ICG NPs was considerably longer than that of free ICG. These novel NPs also displayed a high efficiency of tumor targeting. Conclusions: SPIO@DSPE-PEG/ICG NPs are promising PAT contrast agents for clinical applications.; National Key Research and Development Program of China; State Key Program of National Natural Science of China; National Natural Science Foundation for Distinguished Young Scholars; National Natural Science Foundation of China; the Foundation for Innovative Research Groups of the National Natural Science Foundation of China; PubMed; 中国科学引文数据库(CSCD); 3; 349-359; 13
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/457137]
专题	工学院
推荐引用方式 GB/T 7714	Chuang Gao,Zi-Jian Deng,Dong Peng,et al. Near-infrared dye-loaded magnetic nanoparticles as photoacoustic contrast agent for enhanced tumor imaging[J]. 癌症生物学与医学（英文版）,2016.
APA	Chuang Gao.,Zi-Jian Deng.,Dong Peng.,Yu-Shen Jin.,Yan Ma.,...&Xiao-Long Liang.(2016).Near-infrared dye-loaded magnetic nanoparticles as photoacoustic contrast agent for enhanced tumor imaging.癌症生物学与医学（英文版）.
MLA	Chuang Gao,et al."Near-infrared dye-loaded magnetic nanoparticles as photoacoustic contrast agent for enhanced tumor imaging".癌症生物学与医学（英文版） (2016).