Novel Osteogenic Ti-6Al-4V Device For Restoration Of Dental Function In   Patients With Large Bone Deficiencies: Design, Development And   Implementation

doi:10.1038/srep20493

CORC > 北京大学 > 工学院

	Novel Osteogenic Ti-6Al-4V Device For Restoration Of Dental Function In Patients With Large Bone Deficiencies: Design, Development And Implementation
	Cohen, D. J. ; Cheng, A. ; Kahn, A. ; Aviram, M. ; Whitehead, A. J. ; Hyzy, S. L. ; Clohessy, R. M. ; Boyan, B. D. ; Schwartz, Z.
刊名	SCIENTIFIC REPORTS
	2016
关键词	MICRO COMPUTED-TOMOGRAPHY OSTEOBLAST LINEAGE CELLS VANADIUM ALLOY SURFACES TITANIUM SURFACE DIFFERENTIAL RESPONSE EDENTULOUS PATIENTS COMPLETE DENTURES IN-VITRO IMPLANTS ROUGHNESS
DOI	10.1038/srep20493
英文摘要	Custom devices supporting bone regeneration and implant placement are needed for edentulous patients with large mandibular deficiencies where endosteal implantation is not possible. We developed a novel subperiosteal titanium-aluminum-vanadium bone onlay device produced by additive manufacturing (AM) and post-fabrication osteogenic micro-/nano-scale surface texture modification. Human osteoblasts produced osteogenic and angiogenic factors when grown on laser-sintered nano-/micro-textured surfaces compared to smooth surfaces. Surface-processed constructs caused higher bone-to-implant contact, vertical bone growth into disk pores (microCT and histomorphometry), and mechanical pull-out force at 5 and 10 w on rat calvaria compared to non surface-modified constructs, even when pre-treating the bone to stimulate osteogenesis. Surface-modified wrap-implants placed around rabbit tibias osseointegrated by 6 w. Finally, patient-specific constructs designed to support dental implants produced via AM and surface-processing were implanted on edentulous mandibular bone. 3 and 8 month post-operative images showed new bone formation and osseointegration of the device and indicated stability of the dental implants.; National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health [AR052102]; AB Dental; National Science Foundation Graduate Research Fellowship; SCI(E); ARTICLE; bboyan@vcu.edu; 6
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/438657]
专题	工学院
推荐引用方式 GB/T 7714	Cohen, D. J.,Cheng, A.,Kahn, A.,et al. Novel Osteogenic Ti-6Al-4V Device For Restoration Of Dental Function In Patients With Large Bone Deficiencies: Design, Development And Implementation[J]. SCIENTIFIC REPORTS,2016.
APA	Cohen, D. J..,Cheng, A..,Kahn, A..,Aviram, M..,Whitehead, A. J..,...&Schwartz, Z..(2016).Novel Osteogenic Ti-6Al-4V Device For Restoration Of Dental Function In Patients With Large Bone Deficiencies: Design, Development And Implementation.SCIENTIFIC REPORTS.
MLA	Cohen, D. J.,et al."Novel Osteogenic Ti-6Al-4V Device For Restoration Of Dental Function In Patients With Large Bone Deficiencies: Design, Development And Implementation".SCIENTIFIC REPORTS (2016).