Fabrication of a Multimodal Microbubble Platform for Magnetic Resonance,   Ultrasound and Fluorescence Imaging Application

doi:10.1166/jnn.2016.10952

CORC > 北京大学 > 工学院

	Fabrication of a Multimodal Microbubble Platform for Magnetic Resonance, Ultrasound and Fluorescence Imaging Application
	Miao, Zhaohua ; Guo, Caixin ; Li, Zhenglin ; Jin, Yushen ; Ke, Hengte ; Dai, Zhifei
刊名	JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
	2016
关键词	Multimodal Microbubble Contrast Agents MRI Ultrasound Fluorescence CONTRAST AGENTS IN-VIVO QUANTUM DOTS NANOPARTICLES NANOCOMPOSITES NANOCRYSTALS LUMINESCENCE MULTILAYERS RELAXIVITY COMPLEX
DOI	10.1166/jnn.2016.10952
英文摘要	Magnetic resonance (MR), ultrasound (US) and fluorescence imaging are the widely used diagnostic modalities for various experimental and clinical applications. A multimodal poly(lactic acid) microbubble (MB) integrated with the three imaging modalities was fabricated by adsorbing CdTe quantum dots (QDs) onto the surface and encapsulating superparamagnetic iron oxide (SPIO) nanoparticles into the core. The strong fluorescence of the multimodal MBs confirmed that QDs were successfully deposited onto the surface. The in vitro MRI contrasting capability of the multimodal MBs at various concentrations was evaluated by T-2-weighted imaging. Furthermore, the in vitro and in vivo ultrasonography indicated that CdTe and SPIO-inclusive MBs maintained excellent ultrasound contrast property. These results implied that the nano-in-micro hybrid materials have the potential as a nanomedical platform for multimodal bioimaging.; National Natural Science Foundation of China [81371580, 21273014, 81101094]; National Natural Science Foundation for Distinguished Young Scholars [81225011]; State Key Program of National Natural Science of China [81230036]; SCI(E); EI; ARTICLE; 3; 2301-2306; 16
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/437635]
专题	工学院
推荐引用方式 GB/T 7714	Miao, Zhaohua,Guo, Caixin,Li, Zhenglin,et al. Fabrication of a Multimodal Microbubble Platform for Magnetic Resonance, Ultrasound and Fluorescence Imaging Application[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2016.
APA	Miao, Zhaohua,Guo, Caixin,Li, Zhenglin,Jin, Yushen,Ke, Hengte,&Dai, Zhifei.(2016).Fabrication of a Multimodal Microbubble Platform for Magnetic Resonance, Ultrasound and Fluorescence Imaging Application.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY.
MLA	Miao, Zhaohua,et al."Fabrication of a Multimodal Microbubble Platform for Magnetic Resonance, Ultrasound and Fluorescence Imaging Application".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY (2016).