Magnesium-calcium/hydroxyapatite (Mg-Ca/HA) composites with enhanced   bone differentiation properties for orthopedic applications

doi:10.1016/j.matlet.2016.03.005

CORC > 北京大学 > 工学院

	Magnesium-calcium/hydroxyapatite (Mg-Ca/HA) composites with enhanced bone differentiation properties for orthopedic applications
	Lim, P. N. ; Lam, R. N. ; Zheng, Y. F. ; Thian, E. S.
刊名	MATERIALS LETTERS
	2016
关键词	Hydroxyapatite Magnesium-calcium Composites Stem cells IN-VITRO OSTEOBLASTIC CELLS ALLOYS HYDROXYAPATITE BEHAVIOR
DOI	10.1016/j.matlet.2016.03.005
英文摘要	Mg-1Ca/HA composites were produced by blending magnesium-calcium (1 wt%) (Mg-1Ca) alloys with 5, 10 and 15 wt% of hydroxyapatite (HA). Morphology, elemental and phase composition of Mg-1Ca/HA composites were examined. Biocompatibility assessments were also performed using an indirect contact method by culturing human adipose mesenchymal stem cells (hASCs) in the extracts of Mg-1Ca alloy, Mg-1Ca/HA composites and Dulbecco's modified eagle's medium. Mg-1Ca/HA composites could promote cell proliferation and at the same time, enhanced collagen type I (COL I) and osteocalcin (OCN) expressions of hASCs. Among the Mg-1Ca/HA composites, 10 wt% of HA is the optimum amount to be added into Mg-1Ca alloy for enhanced bioactivity, thus emerging as a potential biomaterial for orthopedic fixation. (C) 2016 Elsevier B.V. All rights reserved.; Ministry of Education Academic Research Fund (Singapore) [MOE2013-T2-1-074]; National Basic Research Program of China (973 Program) [2012CB619102]; National Science Fund for Distinguished Young Scholars [51225101]; National Natural Science Foundation of China [51431002, 31170909]; Beijing Municipal Science and Technology Project [Z141100002814008]; SCI(E); EI; ARTICLE; yfzheng@pku.edu.cn; mpetes@nus.edu.sg; 193-197; 172
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/437216]
专题	工学院
推荐引用方式 GB/T 7714	Lim, P. N.,Lam, R. N.,Zheng, Y. F.,et al. Magnesium-calcium/hydroxyapatite (Mg-Ca/HA) composites with enhanced bone differentiation properties for orthopedic applications[J]. MATERIALS LETTERS,2016.
APA	Lim, P. N.,Lam, R. N.,Zheng, Y. F.,&Thian, E. S..(2016).Magnesium-calcium/hydroxyapatite (Mg-Ca/HA) composites with enhanced bone differentiation properties for orthopedic applications.MATERIALS LETTERS.
MLA	Lim, P. N.,et al."Magnesium-calcium/hydroxyapatite (Mg-Ca/HA) composites with enhanced bone differentiation properties for orthopedic applications".MATERIALS LETTERS (2016).