Reduction of Dual-task Costs by Noninvasive Modulation of Prefrontal   Activity in Healthy Elders

doi:10.1162/jocn_a_00897

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	Reduction of Dual-task Costs by Noninvasive Modulation of Prefrontal Activity in Healthy Elders
	Manor, Brad ; Zhou, Junhong ; Jor&apos ; Zhang, Jue ; Fang, Jing ; Pascual-Leone, Alvaro ; dan, Azizah
刊名	JOURNAL OF COGNITIVE NEUROSCIENCE
	2016
关键词	DIRECT-CURRENT STIMULATION HUMAN MOTOR CORTEX OLDER-ADULTS POSTURAL CONTROL COGNITIVE RESERVE BRAIN-STIMULATION WORKING-MEMORY PERFORMANCE GAIT WALKING
DOI	10.1162/jocn_a_00897
英文摘要	Dual tasking (e.g., walking or standing while performing a cognitive task) disrupts performance in one or both tasks, and such dual-task costs increase with aging into senescence. Dual tasking activates a network of brain regions including pFC. We therefore hypothesized that facilitation of prefrontal cortical activity via transcranial direct current stimulation (tDCS) would reduce dual-task costs in older adults. Thirty-seven healthy older adults completed two visits during which dual tasking was assessed before and after 20 min of real or sham tDCS targeting the left pFC. Trials of single-task standing, walking, and verbalized serial subtractions were completed, along with dual-task trials of standing or walking while performing serial subtractions. Dual-task costs were calculated as the percent change in markers of gait and postural control and serial subtraction performance, from single to dual tasking. Significant dual-task costs to standing, walking, and serial subtraction performance were observed before tDCS (p < .01). These dual-task costs were less after real tDCS as compared with sham tDCS as well as compared with either pre-tDCS condition (p < .03). Further analyses indicated that tDCS did not alter single task performance but instead improved performance solely within dual-task conditions (p < .02). These results demonstrate that dual tasking can be improved by modulating prefrontal activity, thus indicating that dual-task decrements are modifiable and may not necessarily reflect an obligatory consequence of aging. Moreover, tDCS may ultimately serve as a novel approach to preserving dual-task capacity into senescence.; Dr. Ralph and Marian Falk Medical Research Trust; National Natural Science Foundation of China [11372013]; KL2 Medical Research Investigator Training (MeRIT) award from Harvard Catalyst [1KL2RR02575704]; NIA career development grant [1-K01-AG044543-01A1]; National Institutes of Health [R01HD069776, R01NS073601, R21 MH099196, R21 NS082870, R21 NS085491, R21 HD07616]; Sidney R. Baer Jr. Foundation; Harvard Catalyst \ The Harvard Clinical and Translational Science Center (NCRR and the NCATS NIH) [UL1 RR025758]; SCI(E); PubMed; SSCI; ARTICLE; zhangjue@pku.edu.cn; 2; 275-281; 28
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/436050]
专题	工学院
推荐引用方式 GB/T 7714	Manor, Brad,Zhou, Junhong,Jor&apos,et al. Reduction of Dual-task Costs by Noninvasive Modulation of Prefrontal Activity in Healthy Elders[J]. JOURNAL OF COGNITIVE NEUROSCIENCE,2016.
APA	Manor, Brad.,Zhou, Junhong.,Jor&apos.,Zhang, Jue.,Fang, Jing.,...&dan, Azizah.(2016).Reduction of Dual-task Costs by Noninvasive Modulation of Prefrontal Activity in Healthy Elders.JOURNAL OF COGNITIVE NEUROSCIENCE.
MLA	Manor, Brad,et al."Reduction of Dual-task Costs by Noninvasive Modulation of Prefrontal Activity in Healthy Elders".JOURNAL OF COGNITIVE NEUROSCIENCE (2016).