In vitro investigation of NiTiW shape memory alloy as potential   biomaterial with enhanced radiopacity

doi:10.1016/j.msec.2015.12.006

CORC > 北京大学 > 工学院

	In vitro investigation of NiTiW shape memory alloy as potential biomaterial with enhanced radiopacity
	Li, Huafang ; Cong, Ying ; Zheng, Yufeng ; Cui, Lishan
刊名	MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
	2016
关键词	Metals and alloys Shape memory alloys (SMAs) Phase transformation Radiopacity Corrosion behavior Biomaterials BIOMEDICAL APPLICATIONS STENTS
DOI	10.1016/j.msec.2015.12.006
英文摘要	In the present study, a novel kind of NiTiW shape memory alloy with chemical composition of Ni43.5Ti45.5W11 (at.%) has been successfully developed with excellent X-ray radiopacity by the introduction of pure W precipitates into the NiTi matrix phase. Its microstructure, X-ray radiopacity, mechanical properties, corrosion resistance in simulated body fluid, hemocompatibility and in vitro cytocompatibility were systematically investigated. The typical microstructural feature of NiTiW alloy at room temperature was tiny pure W particles randomly distributing in the NiTi matrix phase. The presence of W precipitates was found to result in enhanced radiopacity and microhardness of NiTiW alloy in comparison to that of NiTi binary alloy. NiTiW alloy exhibits excellent shape memory effect, and a maximum shape recovery ratio of about 30% was obtained with a total prestrain of 8% for the NiTiW alloy sample. In the electrochemical test, NiTiW alloy, presented an excellent corrosion resistance in simulated body fluid, comparable to that of NiTi alloy. Hemocompatibility tests indicated that the NiTiW alloy has quite low hemolysis (lower than 0.5%) and the adherent platelet showed round shape without pseudo pod. Besides, in vitro cell viability tests demonstrated that the cell viability is all above 90%, and the cells spread well on the NiTiW alloy, having polygon or spindle healthy morphology. The hemocompatibility tests, in vitro cell viability tests and morphology observation indicated that the NiTiW shape memory alloys have excellent bio-compatibility. The excellent X-ray radiopacity makes the NiTiW alloys show obvious advantages in orthopedic, stomatological, neurological and cardiovascular domains where radiopacity is quite important factor in order to guarantee successful implantation. (C) 2015 Elsevier B.V. All rights reserved.; National Basic Research Program of China (973 Program) [2012CB619102, 2012CB619100]; National Science Fund for Distinguished Young Scholars [51225101]; National Natural Science Foundation of China [51431002, 31170909]; NSFC/RGC Joint Research Scheme [51361165101]; Beijing Municipal Science and Technology Project [Z141100002814008]; SCI(E); EI; PubMed; ARTICLE; yfzheng@pku.edu.cn; 554-559; 60
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/435660]
专题	工学院
推荐引用方式 GB/T 7714	Li, Huafang,Cong, Ying,Zheng, Yufeng,et al. In vitro investigation of NiTiW shape memory alloy as potential biomaterial with enhanced radiopacity[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2016.
APA	Li, Huafang,Cong, Ying,Zheng, Yufeng,&Cui, Lishan.(2016).In vitro investigation of NiTiW shape memory alloy as potential biomaterial with enhanced radiopacity.MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS.
MLA	Li, Huafang,et al."In vitro investigation of NiTiW shape memory alloy as potential biomaterial with enhanced radiopacity".MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2016).