Morphometric and hemodynamic analysis of atherosclerotic progression in   human carotid artery bifurcations

doi:10.1152/ajpheart.00464.2015

CORC > 北京大学 > 工学院

	Morphometric and hemodynamic analysis of atherosclerotic progression in human carotid artery bifurcations
	Huang, Xu ; Yin, Xiaoping ; Xu, Yingjin ; Jia, Xinwei ; Li, Jianhui ; Niu, Pei ; Shen, Wenzeng ; Kassab, Ghassan S. ; Tan, Wenchang ; Huo, Yunlong
刊名	AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
	2016
关键词	carotid artery bifurcation stenosis atherosclerosis computed tomography angiography AMERICAN-HEART-ASSOCIATION FLOW PATTERNS SHEAR-STRESS VASCULAR-LESIONS GEOMETRY ANATOMY DISEASE RISK TREE ARTERIOSCLEROSIS
DOI	10.1152/ajpheart.00464.2015
英文摘要	Although atherosclerosis has been widely investigated at carotid artery bifurcation, there is a lack of morphometric and hemodynamic data at different stages of the disease. The purpose of this study was to determine the lesion difference in patients with carotid artery disease compared with healthy control subjects. The three-dimensional (3D) geometry of carotid artery bifurcation was reconstructed from computed tomography angiography (CTA) images of Chinese control subjects (n = 30) and patients with carotid artery disease (n = 30). We defined two novel vector angles (i.e., angles 1 and 2) that were tangential to the reconstructed contour of the 3D vessel. The best-fit diameter was computed along the internal carotid artery (ICA) center line. Hemodynamic analysis was performed at various bifurcations. Patients with stenotic vessels have larger angles 1 and 2 (151 +/- 11 degrees and 42 +/- 20 degrees) and smaller diameters of the external carotid artery (ECA) (4.6 +/- 0.85 mm) compared with control subjects (144 +/- 13 degrees and 36 +/- 16 degrees, 5.2 +/- 0.57 mm) although there is no significant difference in the common carotid artery (CCA) (7.1 +/- 1.2 vs. 7.5 +/- 1.0 mm, P = 0.18). In particular, all patients with carotid artery disease have a stenosis at the proximal ICA (including both sinus and carina regions), while 20% of patients have stenosis at the middle ICA and 20% have stenosis expansion to the entire cervical ICA. Morphometric and hemodynamic analyses suggest that atherosclerotic plaques initiate at both sinus and carina regions of ICA and progress downstream.; Natural Science Foundation of China [11372010]; China MOST Grant [2014DFG32740]; SCI(E); PubMed; ARTICLE; yhuo@pku.edu.cn; 5; H639-H647; 310
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/435447]
专题	工学院
推荐引用方式 GB/T 7714	Huang, Xu,Yin, Xiaoping,Xu, Yingjin,et al. Morphometric and hemodynamic analysis of atherosclerotic progression in human carotid artery bifurcations[J]. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY,2016.
APA	Huang, Xu.,Yin, Xiaoping.,Xu, Yingjin.,Jia, Xinwei.,Li, Jianhui.,...&Huo, Yunlong.(2016).Morphometric and hemodynamic analysis of atherosclerotic progression in human carotid artery bifurcations.AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY.
MLA	Huang, Xu,et al."Morphometric and hemodynamic analysis of atherosclerotic progression in human carotid artery bifurcations".AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2016).