Hemodynamics of left internal mammary artery bypass graft: Effect of   anastomotic geometry, coronary artery stenosis, and postoperative time

doi:10.1016/j.jbiomech.2016.01.031

CORC > 北京大学 > 工学院

	Hemodynamics of left internal mammary artery bypass graft: Effect of anastomotic geometry, coronary artery stenosis, and postoperative time
	Fan, Tingting ; Lu, Yuan ; Gao, Yan ; Meng, Jie ; Tan, Wenchang ; Huo, Yunlong ; Kassab, Ghassan S.
刊名	JOURNAL OF BIOMECHANICS
	2016
关键词	Wall shear stress Oscillatory shear index Flow pattern CABG ASSOCIATION TASK-FORCE TO-SIDE ANASTOMOSES WALL SHEAR-STRESS BLOOD-FLOW PRACTICE GUIDELINES COMPETITIVE FLOW MODEL SURGERY DISEASE PATENCY
DOI	10.1016/j.jbiomech.2016.01.031
英文摘要	Although the left internal mammary artery (LIMA) bypass graft is the best choice for surgical revascularization, its hemodynamics are still complex and can result in long-term graft failure. Here, we performed a hemodynamic analysis of the LIMA-coronary artery with end-to-side/side-to-side anastomoses based on 15 patient-specific CTA images at various postoperative periods. We hypothesize that hemodynamic patterns are determined by the interplay of LIMA geometry, anastomotic configuration, and severity of native coronary artery stenosis, which are strongly affected by the postoperative time. A 3D finite volume method with the inlet pressure wave and outlet resistance boundary conditions was used to compute the distribution of pressure and flow, from which the time-averaged wall shear stress (TAWSS), oscillation shear index (OSI), time-averaged WSS gradient (TAWSSG), and transverse WSS (transWSS) were determined. To characterize the hemodynamic environment, we defined surface area ratios of low TAWSS (<= 4 dynes/cm(2)), high OSI (>= 0.15), TAWSSG (>= 500 dynes/cm(3)), and transWSS (>= 6 dynes/cm(2)) in the LIMA graft and at the anastomosis between LIMA graft and coronary artery. These ratios were determined by the interplay of multiple morphometric parameters in the LIMA-coronary artery, but increased with postoperative time. These findings have significant implications for understanding LIMA graft patency. (C) 2016 Elsevier Ltd. All rights reserved.; National Natural Science Foundation of China [11372010]; Ministry of Science and Technology of China, China [2014DFG32740]; SCI(E); EI; PubMed; ARTICLE; yhuo@pku.edu.cn; gkassab@calmi2.org; 5; 645-652; 49
语种	中文
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/434796]
专题	工学院
推荐引用方式 GB/T 7714	Fan, Tingting,Lu, Yuan,Gao, Yan,et al. Hemodynamics of left internal mammary artery bypass graft: Effect of anastomotic geometry, coronary artery stenosis, and postoperative time[J]. JOURNAL OF BIOMECHANICS,2016.
APA	Fan, Tingting.,Lu, Yuan.,Gao, Yan.,Meng, Jie.,Tan, Wenchang.,...&Kassab, Ghassan S..(2016).Hemodynamics of left internal mammary artery bypass graft: Effect of anastomotic geometry, coronary artery stenosis, and postoperative time.JOURNAL OF BIOMECHANICS.
MLA	Fan, Tingting,et al."Hemodynamics of left internal mammary artery bypass graft: Effect of anastomotic geometry, coronary artery stenosis, and postoperative time".JOURNAL OF BIOMECHANICS (2016).