In Vitro Corrosion and Cytocompatibility of a Microarc Oxidation Coating   and Poly(L-lactic acid) Composite Coating on Mg-1Li-1Ca Alloy for   Orthopedic Implants

doi:10.1021/acsami.6b00527

CORC > 北京大学 > 工学院

	In Vitro Corrosion and Cytocompatibility of a Microarc Oxidation Coating and Poly(L-lactic acid) Composite Coating on Mg-1Li-1Ca Alloy for Orthopedic Implants
	Zeng, Rong-Chang ; Cui, Lan-yue ; Jiang, Ke ; Liu, Rui ; Zhao, Bao-Dong ; Zheng, Yu-Feng
刊名	ACS APPLIED MATERIALS & INTERFACES
	2016
关键词	magnesium alloy degradation microarc oxidation poly(L-lactic acid) biomaterial PLASMA ELECTROLYTIC OXIDATION MAGNESIUM ALLOYS HYDROLYTIC DEGRADATION POLY(LACTIC ACID) COATED MAGNESIUM TISSUE-RESPONSE MG ALLOY FILM RESISTANCE BEHAVIOR
DOI	10.1021/acsami.6b00527
英文摘要	Manipulating the degradation rate of biomedical magnesium alloys poses a challenge. The characteristics of a microarc oxidation (MAO), prepared in phytic acid, and poly(L-lactic acid) (PLLA) composite coating, fabricated on a novel Mg-1Li-1Ca alloy, were studied through field emission scanning electron microscopy (FE-SEM), electron probe X-ray microanalysis (EPMA), energy dispersive X-ray spectroscopy (EDS) and X-ray diffraction (XRD). The corrosion behaviors of the samples were evaluated via hydrogen evolution, potentiodynamic polarization and electrochemical impedance spectroscopy in Hanks' solution. The results indicated that the MAO/PLLA composite coatings significantly enhanced the corrosion resistance of the Mg-1Li-1Ca alloy. MTT and ALP assays using MC3T3 osteoblasts indicated that the MAO/PLLA coatings greatly improved the cytocompatibility, and the morphology of the cells cultured on different samples exhibited good adhesion. Hemolysis tests showed that the composite coatings endowed the Mg-1Li-1Ca alloys with a low hemolysis ratio. The increased solution pH resulting from the corrosion of magnesium could be tailored by the degradation of PLLA. The degradation mechanism of the composite coatings was discussed. The MAO/PLLA composite coating may be appropriate for applications on degradable Mg-based orthopedic implants.; National Natural Science Foundation of China [51571134]; SDUST (Shandong University of Science and Technology) Research Fund [2014TDJH104]; Joint Innovative Centre for Safe and Effective Mining Technology and Equipment of Coal Resources, Shandong Province; SCI(E); EI; PubMed; ARTICLE; rczeng@foxmail.com; zbd315@sina.com; 15; 10014-10028; 8
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/434341]
专题	工学院
推荐引用方式 GB/T 7714	Zeng, Rong-Chang,Cui, Lan-yue,Jiang, Ke,et al. In Vitro Corrosion and Cytocompatibility of a Microarc Oxidation Coating and Poly(L-lactic acid) Composite Coating on Mg-1Li-1Ca Alloy for Orthopedic Implants[J]. ACS APPLIED MATERIALS & INTERFACES,2016.
APA	Zeng, Rong-Chang,Cui, Lan-yue,Jiang, Ke,Liu, Rui,Zhao, Bao-Dong,&Zheng, Yu-Feng.(2016).In Vitro Corrosion and Cytocompatibility of a Microarc Oxidation Coating and Poly(L-lactic acid) Composite Coating on Mg-1Li-1Ca Alloy for Orthopedic Implants.ACS APPLIED MATERIALS & INTERFACES.
MLA	Zeng, Rong-Chang,et al."In Vitro Corrosion and Cytocompatibility of a Microarc Oxidation Coating and Poly(L-lactic acid) Composite Coating on Mg-1Li-1Ca Alloy for Orthopedic Implants".ACS APPLIED MATERIALS & INTERFACES (2016).