Targeted Aucore-Agshell nanorods as a dual-functional contrast agent for   photoacoustic imaging and photothermal therapy

doi:10.1364/BOE.7.001830

CORC > 北京大学 > 工学院

	Targeted Aucore-Agshell nanorods as a dual-functional contrast agent for photoacoustic imaging and photothermal therapy
	Shi, Yiwen ; Peng, Dong ; Wang, Kun ; Chai, Xinyu ; Ren, Qiushi ; Tian, Jie ; Zhou, Chuanqing
刊名	BIOMEDICAL OPTICS EXPRESS
	2016
关键词	COATED GOLD NANORODS SILVER NANOPARTICLES SHELL NANORODS CANCER-CELLS NANOSPHERES TOMOGRAPHY NANOSILVER RELEASE SURFACE IONS
DOI	10.1364/BOE.7.001830
英文摘要	Optimizing contrast enhancement is essential for producing specific signals in biomedical imaging and therapy. The potential of using Au-core-Ag-shell nanorods (Au@Ag NRs) as a dual-functional theranostic contrast agent is demonstrated for effective cancer imaging and treatments. Due to its strong NIR absorption and high efficiency of photothermal conversion, effects of both photoacoustic tomography (PAT) and photothermal therapy (PTT) are enhanced significantly. The PAT signal grows by 45.3% and 82% in the phantom and in vivo experiments, respectively, when compared to those using Au NRs. In PTT, The maximum increase of tissue temperature treated with Au@Ag NRs is 22.8 degrees C, twice that with Au NRs. Results of the current study show the feasibility of using Au@Ag NRs for synergetic PAT with PTT. And it will enhance the potential application on real-time PAT guided PTT, which will greatly benefit the customized PTT treatment of cancer. (C) 2016 Optical Society of America; National Basic Research Program of China [2010CB933903, 2014CB748600, 2015CB755500]; National Natural Science Foundation of China [81171377, 81470083]; Chinese Academy of Sciences [YZ201359]; SCI(E); EI; PubMed; ARTICLE; zhoucq@sjtu.edu.cn; 5; 1830-1841; 7
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/433567]
专题	工学院
推荐引用方式 GB/T 7714	Shi, Yiwen,Peng, Dong,Wang, Kun,et al. Targeted Aucore-Agshell nanorods as a dual-functional contrast agent for photoacoustic imaging and photothermal therapy[J]. BIOMEDICAL OPTICS EXPRESS,2016.
APA	Shi, Yiwen.,Peng, Dong.,Wang, Kun.,Chai, Xinyu.,Ren, Qiushi.,...&Zhou, Chuanqing.(2016).Targeted Aucore-Agshell nanorods as a dual-functional contrast agent for photoacoustic imaging and photothermal therapy.BIOMEDICAL OPTICS EXPRESS.
MLA	Shi, Yiwen,et al."Targeted Aucore-Agshell nanorods as a dual-functional contrast agent for photoacoustic imaging and photothermal therapy".BIOMEDICAL OPTICS EXPRESS (2016).