Impaired interhemispheric synchrony in Parkinson&apos;s disease with   depression

doi:10.1038/srep27477

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	Impaired interhemispheric synchrony in Parkinson's disease with depression
	Zhu, Yajing ; Song, Xiaopeng ; Xu, Mingze ; Hu, Xiao ; Li, Erfeng ; Liu, Jiajia ; Yuan, Yonggui ; Gao, Jia-Hong ; Liu, Weiguo
刊名	SCIENTIFIC REPORTS
	2016
关键词	VOXEL-BASED MORPHOMETRY PREFRONTAL CORTEX MAJOR DEPRESSION FUNCTIONAL MRI BASAL GANGLIA GRAY-MATTER BRAIN CEREBELLUM SYMPTOMS DISORDER
DOI	10.1038/srep27477
英文摘要	The alterations of interhemispheric resting-state functional connectivity (FC) in Parkinson's disease (PD) with depression remain unclear, so we aimed to explore the differences of interhemispheric FC between PD with and without depression. Twenty-one depressed PD (DPD) patients, 49 non-depressed PD (NDPD) patients and 50 matched healthy controls (HC) participated in this study. Resting-state functional magnetic resonance imaging (fMRI) data were analyzed with the voxel-mirrored homotopic connectivity (VMHC) approach. The DPD patients showed lower VMHC values in the bilateral dorsolateral prefrontal cortex (DLPFC) and calcarine cortex compared to both NDPD and HC groups, and further receiver operating characteristic curves (ROC) analyses revealed that the VMHC in these two brain areas could be used as biomarkers to distinguish DPD from NDPD and from HC. The pooled PD patients (both DPD and NDPD) exhibited decreased VMHC in the bilateral putamen, middle occipital gyrus (MOG), postcentral gyrus (PoCG), paracentral lobule (PCL) and cerebellum posterior lobe when compared with HC. Decreased VMHC values within the DLPFC and calcarine cortex appeared to be unique features for DPD and might be used as potential neuroimaging markers to distinguish DPD patients from NDPD and HC groups. These findings may underlie the neural mechanisms of depression in PD.; National Nature Science Foundation of China [61431013, 61131003, 81430037, 31421003, 81227003]; China's National Strategic Basic Research Program (973) [2012CB720700]; SCI(E); PubMed; ARTICLE; wgliubh@sina.com; 27477; 6
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/433455]
专题	工学院
推荐引用方式 GB/T 7714	Zhu, Yajing,Song, Xiaopeng,Xu, Mingze,et al. Impaired interhemispheric synchrony in Parkinson's disease with depression[J]. SCIENTIFIC REPORTS,2016.
APA	Zhu, Yajing.,Song, Xiaopeng.,Xu, Mingze.,Hu, Xiao.,Li, Erfeng.,...&Liu, Weiguo.(2016).Impaired interhemispheric synchrony in Parkinson's disease with depression.SCIENTIFIC REPORTS.
MLA	Zhu, Yajing,et al."Impaired interhemispheric synchrony in Parkinson's disease with depression".SCIENTIFIC REPORTS (2016).