GX1-conjugated poly(lactic acid) nanoparticles encapsulating Endostar   for improved in vivo anticolorectal cancer treatment

doi:10.2147/IJN.S82029

CORC > 北京大学 > 工学院

	GX1-conjugated poly(lactic acid) nanoparticles encapsulating Endostar for improved in vivo anticolorectal cancer treatment
	Du, Yang ; Zhang, Qian ; Jing, Lijia ; Liang, Xiaolong ; Chi, Chongwei ; Li, Yaqian ; Yang, Xin ; Dai, Zhifei ; Tian, Jie
刊名	INTERNATIONAL JOURNAL OF NANOMEDICINE
	2015
关键词	GX1 peptide Endostar colorectal cancer angiogenesis IRDye 800CW molecular imaging RECOMBINANT HUMAN ENDOSTATIN GASTRIC-CANCER INTEGRIN ALPHA(V)BETA(3) ANTIANGIOGENIC THERAPY TUMOR ANGIOGENESIS TARGETED THERAPY DRUG-DELIVERY VASCULATURE ACTIVATION RESISTANCE
DOI	10.2147/IJN.S82029
英文摘要	Tumor angiogenesis plays a key role in tumor growth and metastasis; thus, targeting tumor-associated angiogenesis is an important goal in cancer therapy. However, the efficient delivery of drugs to tumors remains a key issue in antiangiogenesis therapy. GX1, a peptide identified by phage-display technology, is a novel tumor vasculature endothelium-specific ligand and possesses great potential as a targeted vector and antiangiogenic agent in the diagnosis and treatment of human cancers. Endostar, a novel recombinant human endostatin, has been shown to inhibit tumor angiogenesis. In this study, we developed a theranostic agent composed of GX1-conjugated poly(lactic acid) nanoparticles encapsulating Endostar (GPENs) and labeled with the near-infrared dye IRDye 800CW to improve colorectal tumor targeting and treatment efficacy in vivo. The in vivo fluorescence molecular imaging data showed that GPENs (IRDye 800CW) more specifically targeted tumors than free IRDye 800CW in colorectal tumor-bearing mice. Moreover, the antitumor efficacy was evaluated by bioluminescence imaging and immunohistology, revealing that GPENs possessed improved antitumor efficacy on subcutaneous colorectal xenografts compared to other treatment groups. Thus, our study showed that GPENs, a novel GX1 peptide guided form of nanoscale Endostar, can be used as a theranostic agent to facilitate more efficient targeted therapy and enable real-time monitoring of therapeutic efficacy in vivo.; National Basic Research Program of China (973) [2011CB707702, 2014CB748600, 2015CB755500]; National Natural Science Foundation of China [81227901, 81470083]; State Key Laboratory of Management and Control for Complex Systems [Y3S9021F30]; SCI(E); PubMed; ARTICLE; jie.tian@ia.ac.cn; 3791-3802; 10
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/419393]
专题	工学院
推荐引用方式 GB/T 7714	Du, Yang,Zhang, Qian,Jing, Lijia,et al. GX1-conjugated poly(lactic acid) nanoparticles encapsulating Endostar for improved in vivo anticolorectal cancer treatment[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2015.
APA	Du, Yang.,Zhang, Qian.,Jing, Lijia.,Liang, Xiaolong.,Chi, Chongwei.,...&Tian, Jie.(2015).GX1-conjugated poly(lactic acid) nanoparticles encapsulating Endostar for improved in vivo anticolorectal cancer treatment.INTERNATIONAL JOURNAL OF NANOMEDICINE.
MLA	Du, Yang,et al."GX1-conjugated poly(lactic acid) nanoparticles encapsulating Endostar for improved in vivo anticolorectal cancer treatment".INTERNATIONAL JOURNAL OF NANOMEDICINE (2015).