EVOLVING CONCEPTS OF CHONDROGENIC DIFFERENTIATION: HISTORY,   STATE-OF-THE-ART AND FUTURE PERSPECTIVES

CORC > 北京大学 > 工学院

	EVOLVING CONCEPTS OF CHONDROGENIC DIFFERENTIATION: HISTORY, STATE-OF-THE-ART AND FUTURE PERSPECTIVES
	Tang, X. ; Fan, L. ; Pei, M. ; Zeng, L. ; Ge, Z.
刊名	EUROPEAN CELLS & MATERIALS
	2015
关键词	Chondrogenic differentiation chondrogenesis mesenchymal stem cells chondrocytes chondrogenic differentiation factors MESENCHYMAL STEM-CELLS IN-VITRO CHONDROGENESIS GROWTH-FACTOR-BETA ARTICULAR-CARTILAGE FORMATION LIMB-BUD CHONDROGENESIS HORMONE-RELATED PROTEIN MARROW STROMAL CELLS BONE-MARROW TGF-BETA PROGENITOR CELLS
英文摘要	As a cell source, multipotent mesenchymal stromal cells or mesenchymal stem cells (MSCs) are promising candidates for chondrogenic differentiation and subsequent cartilage regeneration. From previous literature, it is known that chondrogenic differentiation of MSCs inevitably leads to hypertrophy and subsequent endochondral ossification. In this review, we examine the history of currently established protocols of chondrogenic differentiation and elaborate on the roles of individual components of chondrogenic differentiation medium. We also summarise the effects of physical, chemical and biological factors involved, and propose potential strategies to differentiate MSCs into articular chondrocytes with homogenous mature phenotypes through spatial-temporal incorporation of cell differentiation and chondrogenesis.; National Basic Research Program of China (973 Program) [2012CB619100]; National Natural Science Foundation of China [81271722, 81471800]; SCI(E); PubMed; ARTICLE; gez@pku.edu.cn; 12-27; 30
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/418555]
专题	工学院
推荐引用方式 GB/T 7714	Tang, X.,Fan, L.,Pei, M.,et al. EVOLVING CONCEPTS OF CHONDROGENIC DIFFERENTIATION: HISTORY, STATE-OF-THE-ART AND FUTURE PERSPECTIVES[J]. EUROPEAN CELLS & MATERIALS,2015.
APA	Tang, X.,Fan, L.,Pei, M.,Zeng, L.,&Ge, Z..(2015).EVOLVING CONCEPTS OF CHONDROGENIC DIFFERENTIATION: HISTORY, STATE-OF-THE-ART AND FUTURE PERSPECTIVES.EUROPEAN CELLS & MATERIALS.
MLA	Tang, X.,et al."EVOLVING CONCEPTS OF CHONDROGENIC DIFFERENTIATION: HISTORY, STATE-OF-THE-ART AND FUTURE PERSPECTIVES".EUROPEAN CELLS & MATERIALS (2015).