Properties of electrically evoked potentials activated by optic nerve   stimulation with penetrating electrodes of different modes in rabbits

doi:10.1007/s00417-015-3121-0

CORC > 北京大学 > 工学院

	Properties of electrically evoked potentials activated by optic nerve stimulation with penetrating electrodes of different modes in rabbits
	Cao, Pengjia ; Sun, Jingjing ; Yan, Yan ; Chen, Yao ; Chai, Xinyu ; Sun, Xiaodong ; Ren, Qiushi ; Li, Liming
刊名	GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
	2015
关键词	Optic nerve Electrical stimulation EEPs Visual prosthesis Rabbits RETINAL PROSTHESIS VISUAL-CORTEX RETINITIS-PIGMENTOSA BLIND RESPONSES
DOI	10.1007/s00417-015-3121-0
英文摘要	To investigate the effect of different stimulation modes on cortical electrically evoked potentials (EEPs) by intraorbital optic nerve (ON) stimulation with penetrating electrodes. A stimulating electrode array with three electrodes arranged linearly was inserted into the ON along its axis. EEPs were recorded using a 4 x 4 silver-ball electrode array in response to monopolar and bipolar stimulation mode, respectively. The simultaneous monopolar stimulation mode had a lower threshold than the individual monopolar stimulation mode, but elicited smaller cortical response when a fixed charge was injected. The threshold of the bipolar stimulation mode was comparable to that of individual monopolar stimulation mode. The response to the smaller spacing (150 mu m) bipolar stimulation mode was similar in amplitude to that of the individual monopolar stimulation mode, but spread wider. The larger spacing (500 mu m) bipolar stimulation mode elicited stronger and wider response than the individual monopolar stimulation mode. For the individual monopolar stimulation mode, stimulation with different electrodes can be differentiated even when the spacing of the two electrodes was 150 mu m. For ON stimulation with penetrating electrodes, the monopolar stimulation mode could induce more localized cortical responses than the bipolar stimulation mode with comparable threshold and had a high stimulation selectivity. These findings may provide valuable information for the design of stimulation strategy of the penetrative ON visual prosthesis.; National Basic Research Program of China (973 Program) [2011CB707502]; National Natural Science Foundation of China [60971102, 61171174, 91120304]; SCI(E); PubMed; ARTICLE; lilm@sjtu.edu.cn; 12; 2171-2180; 253
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/418515]
专题	工学院
推荐引用方式 GB/T 7714	Cao, Pengjia,Sun, Jingjing,Yan, Yan,et al. Properties of electrically evoked potentials activated by optic nerve stimulation with penetrating electrodes of different modes in rabbits[J]. GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY,2015.
APA	Cao, Pengjia.,Sun, Jingjing.,Yan, Yan.,Chen, Yao.,Chai, Xinyu.,...&Li, Liming.(2015).Properties of electrically evoked potentials activated by optic nerve stimulation with penetrating electrodes of different modes in rabbits.GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY.
MLA	Cao, Pengjia,et al."Properties of electrically evoked potentials activated by optic nerve stimulation with penetrating electrodes of different modes in rabbits".GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY (2015).