Manganese (II) Chelate Functionalized Copper Sulfide Nanoparticles for   Efficient Magnetic Resonance/Photoacoustic Dual-Modal Imaging Guided   Photothermal Therapy

doi:10.7150/thno.11754

CORC > 北京大学 > 工学院

	Manganese (II) Chelate Functionalized Copper Sulfide Nanoparticles for Efficient Magnetic Resonance/Photoacoustic Dual-Modal Imaging Guided Photothermal Therapy
	Liu, Renfa ; Jing, Lijia ; Peng, Dong ; Li, Yong ; Tian, Jie ; Dai, Zhifei
刊名	THERANOSTICS
	2015
关键词	Copper sulfide nanoparticles Nanotheranostic agent Photoacoustic imaging Magnatic resonance imaging Photothermal therapy MRI CONTRAST AGENTS IN-VIVO SYNERGISTIC THERAPY THERANOSTIC AGENT CANCER-CELLS ABLATION PLATFORM PROBE
DOI	10.7150/thno.11754
英文摘要	The integration of diagnostic and therapeutic functionalities into one nanoplatform shows great promise in cancer therapy. In this research, manganese (II) chelate functionalized copper sulfide nanoparticles were successfully prepared using a facile hydrothermal method. The obtained ultrasmall nanoparticles exhibit excellent photothermal effect and photoaoustic activity. Besides, the high loading content of Mn(II) chelates makes the nanoparticles attractive T1 contrast agent in magnetic resonance imaging (MRI). In vivo photoacoustic imaging (PAI) results showed that the nanoparticles could be efficiently accumulated in tumor site in 24 h after systematic administration, which was further validated by MRI tests. The subsequent photothermal therapy of cancer in vivo was achieved without inducing any observed side effects. Therefore, the copper sulfide nanoparticles functionalized with Mn(II) chelate hold great promise as a theranostic nanomedicine for MR/PA dual-modal imaging guided photothermal therapy of cancer.; National Natural Science Foundation for Distinguished Young Scholars [81225011]; State Key Program of National Natural Science of China [81230036]; National Natural Science Foundation of China [21273014]; Foundation for Innovative Research Groups of the National Natural Science Foundation of China [81421004]; SCI(E); PubMed; ARTICLE; zhifei.dai@pku.edu.cn; 10; 1144-1153; 5
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/418399]
专题	工学院
推荐引用方式 GB/T 7714	Liu, Renfa,Jing, Lijia,Peng, Dong,et al. Manganese (II) Chelate Functionalized Copper Sulfide Nanoparticles for Efficient Magnetic Resonance/Photoacoustic Dual-Modal Imaging Guided Photothermal Therapy[J]. THERANOSTICS,2015.
APA	Liu, Renfa,Jing, Lijia,Peng, Dong,Li, Yong,Tian, Jie,&Dai, Zhifei.(2015).Manganese (II) Chelate Functionalized Copper Sulfide Nanoparticles for Efficient Magnetic Resonance/Photoacoustic Dual-Modal Imaging Guided Photothermal Therapy.THERANOSTICS.
MLA	Liu, Renfa,et al."Manganese (II) Chelate Functionalized Copper Sulfide Nanoparticles for Efficient Magnetic Resonance/Photoacoustic Dual-Modal Imaging Guided Photothermal Therapy".THERANOSTICS (2015).