Lu-177-Labeled Cerasomes Encapsulating Indocyanine Green for Cancer   Theranostics

doi:10.1021/acsami.5b07856

CORC > 北京大学 > 工学院

	Lu-177-Labeled Cerasomes Encapsulating Indocyanine Green for Cancer Theranostics
	Jing, Lijia ; Shi, Jiyun ; Fan, Di ; Li, Yaqian ; Liu, Renfa ; Dai, Zhifei ; Wang, Fan ; Tian, Jie
刊名	ACS APPLIED MATERIALS & INTERFACES
	2015
关键词	cerasome indocyanine green multimodal imaging photothermal therapy nanotheranostics MESOPOROUS SILICA NANOPARTICLES TRIGGERED DRUG-RELEASE PHOTOTHERMAL THERAPY IN-VIVO CONTRAST AGENTS GOLD NANOCAGES FLUORESCENCE MICROCAPSULES NANOPROBES EFFICACY
DOI	10.1021/acsami.5b07856
英文摘要	This Article reported the fabrication of a robust theranostic cerasome encapsulating indocyanine green (ICG) by incorporating 1,2-distearoyl-sn-glycero-3-phosphoethanol-amine-N-[carboxy(polyethylene glycol)2000]-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid monoamide (DSPE-PEG(2000)-DOTA), followed by chelating radioisotope of Lu-177. Its applications in optical and nuclear imaging of tumor uptake and biodistribution, as well as photothermal killing of cancer cells, were investigated. It was found that the obtained cerasome could act efficiently as fluorescence contrast agent as well as nuclear imaging tracer. Encapsulating ICG into cerasome could protect ICG from degradation, aggregation, and fast elimination from body, resulting in remarkable improvement in near-infrared fluorescence imaging, photothermal stability, and in vivo pharmacokinetic profile. Both fluorescence and nuclear imaging showed that such agent could selectively accumulate in tumor site after intravenous injection of the cerasome agent into Lewis lung carcinoma tumor bearing mice, resulting in efficient photothermal ablation of tumor through a one-time NIR laser irradiation at the best time window. The ability to track the uptake of cerasomes on a whole body basis could provide researchers with an excellent tool for developing cerasome-based drug delivery agents, especially the strategy of labeling cerasomes with theranostic radionuclide Lu-177, enabling the ability of the Lu-177-labeled cerasomes for radionuclide cancer therapy and even the combined therapy.; State Key Program of the National Natural Science of China [81230036]; National High Technology Research and Development Program of China [2013AA032201]; National Natural Science Foundation of China [21273014, 81321003, 81420108019]; National Natural Science Foundation for Distinguished Young Scholars [81125011, 81225011]; Foundation for Innovative Research Groups; SCI(E); EI; PubMed; ARTICLE; zhifei.dai@pku.edu.cn; wangfan@bjmu.edu.cn; jie.tian@ia.ac.cn; 39; 22095-22105; 7
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/415786]
专题	工学院
推荐引用方式 GB/T 7714	Jing, Lijia,Shi, Jiyun,Fan, Di,et al. Lu-177-Labeled Cerasomes Encapsulating Indocyanine Green for Cancer Theranostics[J]. ACS APPLIED MATERIALS & INTERFACES,2015.
APA	Jing, Lijia.,Shi, Jiyun.,Fan, Di.,Li, Yaqian.,Liu, Renfa.,...&Tian, Jie.(2015).Lu-177-Labeled Cerasomes Encapsulating Indocyanine Green for Cancer Theranostics.ACS APPLIED MATERIALS & INTERFACES.
MLA	Jing, Lijia,et al."Lu-177-Labeled Cerasomes Encapsulating Indocyanine Green for Cancer Theranostics".ACS APPLIED MATERIALS & INTERFACES (2015).