Top-Down Regulation of Default Mode Activity in Spatial Visual Attention

doi:10.1523/JNEUROSCI.4939-12.2013

CORC > 北京大学 > 工学院

	Top-Down Regulation of Default Mode Activity in Spatial Visual Attention
	Wen, Xiaotong ; Liu, Yijun ; Yao, Li ; Ding, Mingzhou
刊名	journal of neuroscience
	2013
关键词	GRANGER CAUSALITY ANALYSIS ANTERIOR CINGULATE CORTEX TRAUMATIC BRAIN-INJURY FUNCTIONAL CONNECTIVITY TIME-SERIES NEURONAL MECHANISMS ALPHA OSCILLATIONS PREFRONTAL CORTEX COGNITIVE CONTROL CONTROL NETWORKS
DOI	10.1523/JNEUROSCI.4939-12.2013
英文摘要	Dorsal anterior cingulate and bilateral anterior insula form a task control network (TCN) whose primary function includes initiating and maintaining task-level cognitive set and exerting top-down regulation of sensorimotor processing. The default mode network (DMN), comprising an anatomically distinct set of cortical areas, mediates introspection and self-referential processes. Resting-state data show that TCN and DMN interact. The functional ramifications of their interaction remain elusive. Recording fMRI data from human subjects performing a visual spatial attention task and correlating Granger causal influences with behavioral performance and blood oxygen level-dependent (BOLD) activity we report three main findings. First, causal influences from TCN to DMN, i.e., TCN -> DMN, are positively correlated with behavioral performance. Second, causal influences from DMN to TCN, i.e., DMN -> TCN, are negatively correlated with behavioral performance. Third, stronger DMN -> TCN are associated with less elevated BOLD activity in TCN, whereas the relationship between TCN -> DMN and DMN BOLD activity is unsystematic. These results suggest that, during visual spatial attention, top-down signals from TCN to DMN regulate the activity in DMN to enhance behavioral performance, whereas signals from DMN to TCN, acting possibly as internal noise, interfere with task control, leading to degraded behavioral performance.; Neurosciences; SCI(E); 16; ARTICLE; 15; 6444-6453; 33
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/391913]
专题	工学院
推荐引用方式 GB/T 7714	Wen, Xiaotong,Liu, Yijun,Yao, Li,et al. Top-Down Regulation of Default Mode Activity in Spatial Visual Attention[J]. journal of neuroscience,2013.
APA	Wen, Xiaotong,Liu, Yijun,Yao, Li,&Ding, Mingzhou.(2013).Top-Down Regulation of Default Mode Activity in Spatial Visual Attention.journal of neuroscience.
MLA	Wen, Xiaotong,et al."Top-Down Regulation of Default Mode Activity in Spatial Visual Attention".journal of neuroscience (2013).