Concentration dependence of optical clearing on the enhancement of   laser-scanning optical-resolution photoacoustic microscopy imaging

doi:10.1117/1.JBO.19.3.036019

CORC > 北京大学 > 工学院

	Concentration dependence of optical clearing on the enhancement of laser-scanning optical-resolution photoacoustic microscopy imaging
	Zhao, Qingliang ; Li, Lin ; Li, Qian ; Jiang, Xia ; Ren, Qiushi ; Chai, Xinyu ; Zhou, Chuanqing
刊名	生物医学光学通讯
	2014
关键词	photoacoustic imaging concentration glycerol tissue optical clearing imaging through turbid media IN-VIVO COHERENCE TOMOGRAPHY HYPEROSMOTIC AGENTS CONTRAST AGENT HUMAN SKIN TISSUES VITRO IMMERSION DIFFUSION LIQUID
DOI	10.1117/1.JBO.19.3.036019
英文摘要	Quantitative analysis of optical clearing effects (OCE) induced by hyperosmotic agents is very important to optical tissue clearing applications in biomedical diagnostic imaging and therapeutics. This study aims at investigating the effect of glycerol concentration on the laser-scanning optical-resolution photoacoustic microscopy (LSOR-PAM) imaging contrast and light penetration depth. The photoacoustic (PA) signal amplitude changes are evaluated as a function of the concentration of glycerol. The results reveal that the PA signal amplitudes are enhanced with the glycerol concentration increasing, and also show that higher concentration of glycerol produces better light penetration and OCE on a phantom. The PA signal amplitude increases only 8.1% for 20% glycerol, but for higher concentrations, the increases are 76% and 165% for 40% and 60% glycerol, respectively. This preliminary study demonstrates that application of glycerol as an optical contrast agent reduces the tissue scattering and is beneficial to PAM imaging and optical diagnosis in clinical dermatology. (C) 2014 Society of Photo-Optical Instrumentation Engineers (SPIE); http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000338333400032&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Biochemical Research Methods; Optics; Radiology, Nuclear Medicine & Medical Imaging; SCI(E); EI; PubMed; 4; ARTICLE; xychai@sjtu.edu.cn; zhoucq@sjtu.edu.cn; 3; 36019; 19
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/342439]
专题	工学院
推荐引用方式 GB/T 7714	Zhao, Qingliang,Li, Lin,Li, Qian,et al. Concentration dependence of optical clearing on the enhancement of laser-scanning optical-resolution photoacoustic microscopy imaging[J]. 生物医学光学通讯,2014.
APA	Zhao, Qingliang.,Li, Lin.,Li, Qian.,Jiang, Xia.,Ren, Qiushi.,...&Zhou, Chuanqing.(2014).Concentration dependence of optical clearing on the enhancement of laser-scanning optical-resolution photoacoustic microscopy imaging.生物医学光学通讯.
MLA	Zhao, Qingliang,et al."Concentration dependence of optical clearing on the enhancement of laser-scanning optical-resolution photoacoustic microscopy imaging".生物医学光学通讯 (2014).