A biomimetic mechanism for antibody immobilization on lipid nanofibers   for cell capture

doi:10.1063/1.4766191

CORC > 北京大学 > 工学院

	A biomimetic mechanism for antibody immobilization on lipid nanofibers for cell capture
	Zha, Zhengbao ; Jiang, Linan ; Dai, Zhifei ; Wu, Xiaoyi
刊名	应用物理学快报
	2012
关键词	biomembrane transport biomimetics cellular biophysics lipid bilayers nanobiotechnology nanofibres CIRCULATING TUMOR-CELLS CANCER-PATIENTS MEMBRANES DOMAINS
DOI	10.1063/1.4766191
英文摘要	The immobilization of membrane-bound molecules on organic-inorganic cholesteryl-succinyl silane (CSS) nanofibers is investigated. Fluorescent microscopy and a cell capture assay confirm the stable and functional immobilization of membrane-bound antibodies and imaging agents on the electrospun CSS nanofibers. An insert-and-tighten mechanism is proposed for the observed hydration-induced reduction in lipid nanofiber diameter, the immobilization of membrane-bound molecules, and the improved efficiency of cell capture by the functionalized CSS nanofibers over their film counterparts. The ability to stably and functionally immobilize membrane-bound molecules on the CSS nanofibers presents a promising method to functionalize lipid-based nanomaterials. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.4766191]; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000311320100071&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Physics, Applied; SCI(E); EI; 4; ARTICLE; 19; 101
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/229307]
专题	工学院
推荐引用方式 GB/T 7714	Zha, Zhengbao,Jiang, Linan,Dai, Zhifei,et al. A biomimetic mechanism for antibody immobilization on lipid nanofibers for cell capture[J]. 应用物理学快报,2012.
APA	Zha, Zhengbao,Jiang, Linan,Dai, Zhifei,&Wu, Xiaoyi.(2012).A biomimetic mechanism for antibody immobilization on lipid nanofibers for cell capture.应用物理学快报.
MLA	Zha, Zhengbao,et al."A biomimetic mechanism for antibody immobilization on lipid nanofibers for cell capture".应用物理学快报 (2012).