Graphene oxide modified PLA microcapsules containing gold nanoparticles   for ultrasonic/CT bimodal imaging guided photothermal tumor therapy

doi:10.1016/j.biomaterials.2013.03.027

CORC > 北京大学 > 工学院

	Graphene oxide modified PLA microcapsules containing gold nanoparticles for ultrasonic/CT bimodal imaging guided photothermal tumor therapy
	Jin, Yushen ; Wang, Jinrui ; Ke, Hengte ; Wang, Shumin ; Dai, Zhifei
刊名	biomaterials
	2013
关键词	Microcapsules Photothermal therapy Computed tomography Ultrasound imaging Theranostic agent ULTRASOUND CONTRAST AGENTS RAY COMPUTED-TOMOGRAPHY IN-VIVO CANCER PLATFORM CELLS
DOI	10.1016/j.biomaterials.2013.03.027
英文摘要	Theranostic microcapsules were successfully fabricated by introducing gold nanoparticles into poly(lactic acid) microcapsules through a double-microemulsion method, followed by depositing graphene oxide onto the microcapsule surface via electrostatic layer-by-layer self-assembly technique. It was proved that the obtained microcapsules could serve as a contrast agent to simultaneously enhance US imaging and X-ray CT imaging greatly both in vitro and in vivo. In addition, the in vivo therapeutic examinations showed that the microcapsule was an effective agent for photothermal therapy of cancer. The near-infrared laser light ablated the tumor completely within 9 days in the presence of the microcapsules and the tumor growth inhibition was 83.8%. The combination of real-time ultrasound with 3-D computed tomography through a single microcapsule agent is very helpful for accurately interpreting the obtained images, identifying the size and location of the tumor, as well as guiding and monitoring the photothermal therapy. Simultaneously, the effectiveness of photothermal therapy could be evaluated by the combined US and CT imaging enhanced by the microcapsule agent. Such a versatile microcapsule system might bring opportunities to the next generation of multimodal imaging guided cancer therapy. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000318464200010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Engineering, Biomedical; Materials Science, Biomaterials; SCI(E); EI; 75; ARTICLE; 20; 4794-4802; 34
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/222430]
专题	工学院
推荐引用方式 GB/T 7714	Jin, Yushen,Wang, Jinrui,Ke, Hengte,et al. Graphene oxide modified PLA microcapsules containing gold nanoparticles for ultrasonic/CT bimodal imaging guided photothermal tumor therapy[J]. biomaterials,2013.
APA	Jin, Yushen,Wang, Jinrui,Ke, Hengte,Wang, Shumin,&Dai, Zhifei.(2013).Graphene oxide modified PLA microcapsules containing gold nanoparticles for ultrasonic/CT bimodal imaging guided photothermal tumor therapy.biomaterials.
MLA	Jin, Yushen,et al."Graphene oxide modified PLA microcapsules containing gold nanoparticles for ultrasonic/CT bimodal imaging guided photothermal tumor therapy".biomaterials (2013).