Penetrating electrode stimulation of the rabbit optic nerve: parameters   and effects on evoked cortical potentials

doi:10.1007/s00417-013-2449-6

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	Penetrating electrode stimulation of the rabbit optic nerve: parameters and effects on evoked cortical potentials
	Sun, Jingjing ; Chen, Yao ; Chai, Xinyu ; Ren, Qiushi ; Li, Liming
刊名	graefes archive for clinical and experimental ophthalmology
	2013
关键词	Electrical stimulation Monopolar Prosthesis Vision EEP Symmetrical/asymmetrical charge-balanced pulses Inter-phase gap ELECTRICAL-STIMULATION VISUAL PROSTHESIS AUDITORY-NERVE NEURAL STIMULATION PULSE DURATION RESPONSES CAT FEASIBILITY CURRENTS RETINA
DOI	10.1007/s00417-013-2449-6
英文摘要	Stimulus parameters, in particular pulse shape, are an important consideration in the application of electrical stimulation when experimentally testing a visual prosthesis. We changed the biphasic pulse shape of several asymmetric charge-balanced pulses to investigate their effect on optic nerve (ON) stimulation and the recorded cortical response. Monopolar platinum-iridium electrodes were implanted into the rabbit's ON behind the eyeball. Electrical evoked potentials (EEPs) were recorded with silver ball electrodes placed on the cortex, and the results quantified. Our results indicate that changing the shape of cathodic-first charge-balanced biphasic pulse (CA) while maintaining charge balance could reduce the current thresholds for stimulation. When stimulated at the same charge density, the stimulus having high-amplitude short-duration (HASD) cathodic phase produced a higher amplitude response, with a larger spatial spread but with a lower current threshold compared with other stimuli. Adding an inter-phase gap between the two phases of the stimulus increased the EEP amplitude, but was saturated at a gap of similar to 0.2 ms; this was most obvious with CA stimulation, which was able to elicit a larger cortical response than that elicited by asymmetrical charge-balanced stimulus pulses with HASD cathodic phase, in contrast to CA without a gap. As the stimulating frequency increased, the amplitudes of the EEP components elicited by CA monotonically decreased. The fastest component (P0) was present with stimulating frequencies as high as 80 Hz, while the slower P1 and P2 disappeared with stimulating frequencies higher than 40 and 20 Hz, respectively. A CA stimulus waveform with an inter-phase gap of 0.2 ms was more efficacious for ON stimulation than other stimulus combinations, and therefore should result in less tissue damage, minimal electrode etching, and lower power consumption if used in a visual prosthesis.; Ophthalmology; SCI(E); 0; ARTICLE; 11; 2545-2554; 251
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/219693]
专题	工学院
推荐引用方式 GB/T 7714	Sun, Jingjing,Chen, Yao,Chai, Xinyu,et al. Penetrating electrode stimulation of the rabbit optic nerve: parameters and effects on evoked cortical potentials[J]. graefes archive for clinical and experimental ophthalmology,2013.
APA	Sun, Jingjing,Chen, Yao,Chai, Xinyu,Ren, Qiushi,&Li, Liming.(2013).Penetrating electrode stimulation of the rabbit optic nerve: parameters and effects on evoked cortical potentials.graefes archive for clinical and experimental ophthalmology.
MLA	Sun, Jingjing,et al."Penetrating electrode stimulation of the rabbit optic nerve: parameters and effects on evoked cortical potentials".graefes archive for clinical and experimental ophthalmology (2013).