Contrast ultrasound-guided photothermal therapy using gold nanoshelled   microcapsules in breast cancer

doi:10.1016/j.ejrad.2013.09.010

CORC > 北京大学 > 工学院

	Contrast ultrasound-guided photothermal therapy using gold nanoshelled microcapsules in breast cancer
	Wang, Shumin ; Dai, Zhifei ; Ke, Hengte ; Qu, Enze ; Qi, Xiaoxu ; Zhang, Kuo ; Wang, Jinrui
刊名	european journal of radiology
	2014
关键词	Phototherapy Ultrasonography Breast neoplasms Nanoparticles Laser therapy Thermal ablation Ultrasound guidance RADIOFREQUENCY ABLATION INITIAL-EXPERIENCE LASER THERAPY CARCINOMA TUMORS
DOI	10.1016/j.ejrad.2013.09.010
英文摘要	Objectives: The purpose of this study was to test whether dual functional gold nano-shelled microcapsules (GNS-MCs) can be used as an ultrasound imaging enhancer and as an optical absorber for photothermal therapy (PTT) in a rodent model of breast cancer. Methods: GNS-MCs were fabricated with an inner air and outer gold nanoshell spherical structure. Photothermal cytotoxicity of GNS-MCs was tested with BT474 cancer cells in vitro and non-obese diabetes-SCID (NOD/SCID) mice with breast cancer. GNS-MCs were injected into the tumor under ultrasound guidance and treated with near-infrared (NIR) laser irradiation. The photothermal ablative effectiveness of GNS-MCs was evaluated by measuring the surface and internal temperature of the tumor as well as the size of the tumor using histological confirmation. Results: NIR laser irradiation resulted in significant tumor cell death in GNS-MCs-treated BT474 cells in vitro. GNS-MCs were able to serve as an ultrasound enhancer to guide the intratumoral injection of GNS-MCs and ensure their uniform distribution. In vivo studies revealed that NIR laser irradiation increased the intratumoral temperature to nearly 70 C for 8 min in GNS-MCs-treated mice. Tumor volumes decreased gradually and tumors were completely ablated in 6 out of 7 mice treated with GNS-MCs and laser irradiation by 17 days after treatment. Conclusion: This study demonstrates that ultrasound-guided PTT with theranostic GNS-MCs is a promising technique for in situ treatment of breast cancer. (C) 2013 Elsevier Ireland Ltd. All rights reserved.; Radiology, Nuclear Medicine & Medical Imaging; SCI(E); PubMed; 2; ARTICLE; jinruiwang@sina.com; 1; 117-122; 83
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/161363]
专题	工学院
推荐引用方式 GB/T 7714	Wang, Shumin,Dai, Zhifei,Ke, Hengte,et al. Contrast ultrasound-guided photothermal therapy using gold nanoshelled microcapsules in breast cancer[J]. european journal of radiology,2014.
APA	Wang, Shumin.,Dai, Zhifei.,Ke, Hengte.,Qu, Enze.,Qi, Xiaoxu.,...&Wang, Jinrui.(2014).Contrast ultrasound-guided photothermal therapy using gold nanoshelled microcapsules in breast cancer.european journal of radiology.
MLA	Wang, Shumin,et al."Contrast ultrasound-guided photothermal therapy using gold nanoshelled microcapsules in breast cancer".european journal of radiology (2014).