Power-law rheology characterization of biological cell properties under   AFM indentation measurement

doi:10.1039/c4ra03111c

CORC > 北京大学 > 工学院

	Power-law rheology characterization of biological cell properties under AFM indentation measurement
	Niu, Tianxiao ; Cao, Guoxin
刊名	rsc advances
	2014
关键词	ATOMIC-FORCE MICROSCOPY TIME-SCALE INVARIANCE SINGLE-CELL VISCOELASTIC PROPERTIES FINITE-ELEMENT CREEP FUNCTION LIVING CELLS ENDOTHELIAL-CELLS STEM-CELLS MECHANICS
DOI	10.1039/c4ra03111c
英文摘要	Using finite element modeling, the mechanical properties of biological cells are investigated based on the power-law rheology (PLR) model under atomic force microscopy (AFM) indentation testing. Three different loading modes, including relaxation tests, quasi-static indentation and dynamic indentation are considered. After correcting the effects of the Hertz contact radius and substrate stiffening, the parameters of E-0 and alpha in the PLR model can be accurately determined from all three loading modes under AFM indentation. In addition, for all the three indentation loading modes, the aforementioned two effects are not sensitive to the material model used for the cell (e. g., the values of a and E-0) but only depend upon the ratio of the indentation depth to the cell thickness. Because the parameters determined from various loading modes can be validated among each other, the AFM indentation will be a very effective route to accurately determine the cell mechanical properties based on the PLR model.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000339554500062&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Chemistry, Multidisciplinary; SCI(E); EI; 1; ARTICLE; caogx@pku.edu.cn; 55; 29291-29299; 4
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/154373]
专题	工学院
推荐引用方式 GB/T 7714	Niu, Tianxiao,Cao, Guoxin. Power-law rheology characterization of biological cell properties under AFM indentation measurement[J]. rsc advances,2014.
APA	Niu, Tianxiao,&Cao, Guoxin.(2014).Power-law rheology characterization of biological cell properties under AFM indentation measurement.rsc advances.
MLA	Niu, Tianxiao,et al."Power-law rheology characterization of biological cell properties under AFM indentation measurement".rsc advances (2014).