Cerasomal doxorubicin with long-term storage stability and controllable   sustained release

doi:10.1016/j.actbio.2012.05.022

CORC > 北京大学 > 工学院

	Cerasomal doxorubicin with long-term storage stability and controllable sustained release
	Jin, Yushen ; Yue, Xiuli ; Zhang, Qingyuan ; Wu, Xiaoyi ; Cao, Zhong ; Dai, Zhifei
刊名	acta biomaterialia
	2012
关键词	Cerasome Doxorubicin Controlled release Sustained release Storage stability BIODEGRADABLE POLYMERIC MICELLES INORGANIC VESICULAR NANOHYBRID IN-VITRO SILICATE SURFACE SERUM-PROTEINS CANCER-THERAPY LIPOSOMES NANOPARTICLES COPOLYMER DELIVERY
DOI	10.1016/j.actbio.2012.05.022
英文摘要	Liposomal nanohybrid cerasomes display a remarkable ability to maintain their size and retain encapsulated doxorubicin (DOX) over a period of 90 days under storage conditions in solution compared with liposomes and liposils. Cerasomes retained 92.1 +/- 2.9% of the drug payload after 90 days storage, much more than liposomes (35.2 +/- 2.5%) and liposils (53.2 +/- 5.5%). Under physiologically relevant conditions cerasomes exhibit a low initial burst in the first 5 h and subsequent sustained release of DOX over the next 150 h. Moreover, the magnitude of the initial burst and the rate of sustained release of DOX from cerasomes can be modulated by incorporating dipalmitoylphosphatidylglycerol (DPPG) in the cerasome structure and altering the ratios of the cerasome-forming lipid and phospholipids. Consequently, a wide range of release profiles can be achieved by altering the vesicle composition. Finally, human ovarian cancer cells are effectively killed by DOX released from cerasomes. Together these results suggest that cerasomes may be a promising drug delivery system for the long-term storage and controllable sustained release of the anticancer drug DOX. (C) 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000307625900019&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Engineering, Biomedical; Materials Science, Biomaterials; SCI(E); PubMed; 17; ARTICLE; 9; 3372-3380; 8
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/153977]
专题	工学院
推荐引用方式 GB/T 7714	Jin, Yushen,Yue, Xiuli,Zhang, Qingyuan,et al. Cerasomal doxorubicin with long-term storage stability and controllable sustained release[J]. acta biomaterialia,2012.
APA	Jin, Yushen,Yue, Xiuli,Zhang, Qingyuan,Wu, Xiaoyi,Cao, Zhong,&Dai, Zhifei.(2012).Cerasomal doxorubicin with long-term storage stability and controllable sustained release.acta biomaterialia.
MLA	Jin, Yushen,et al."Cerasomal doxorubicin with long-term storage stability and controllable sustained release".acta biomaterialia (2012).