Functional Magnetic Nanoparticles for Non-Viral Gene Delivery and MR   Imaging

doi:10.1007/s11095-013-1205-2

CORC > 北京大学 > 工学院

	Functional Magnetic Nanoparticles for Non-Viral Gene Delivery and MR Imaging
	Xing, Ruijun ; Liu, Gang ; Zhu, Jinghan ; Hou, Yanglong ; Chen, Xiaoyuan
刊名	药学研究
	2014
关键词	gene delivery gene therapy magnetic nanoparticles (MNPs) magnetic resonance imaging (MRI) IRON-OXIDE NANOPARTICLES SMALL INTERFERING RNA LOW-MOLECULAR-WEIGHT IN-VIVO DRUG-DELIVERY PAMAM DENDRIMERS BIOMEDICAL APPLICATIONS SURFACE MODIFICATION DNA DELIVERY TRANSFECTION EFFICIENCY
DOI	10.1007/s11095-013-1205-2
英文摘要	Gene therapy is becoming a promising strategy to treat various kinds of genetic and acquired diseases. However, the development of safe, efficient, and targetable gene delivery systems remains a major challenge in gene therapy. The unique material characteristics of magnetic nanoparticles (MNPs), including high surface area, facile surface modification, controllable size, and excellent magnetic properties, make them promising candidates for gene delivery. The engineered MNPs with modifiable functional surfaces and bioactive cores can result in several advantageous diagnostic and therapeutic properties including enhanced magnetic resonance imaging (MRI) signal intensity, long permeation and retention in the circulatory system, specific delivery of therapeutic genes to target sites. In this review, the updated research on the preparation and surface modification of MNPs for gene delivery is summarized.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000336745800003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Chemistry, Multidisciplinary; Pharmacology & Pharmacy; SCI(E); PubMed; 6; REVIEW; gangliu.cmitm@xmu.edu.cn; hou@pku.edu.cn; 6; 1377-1389; 31
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/153882]
专题	工学院
推荐引用方式 GB/T 7714	Xing, Ruijun,Liu, Gang,Zhu, Jinghan,et al. Functional Magnetic Nanoparticles for Non-Viral Gene Delivery and MR Imaging[J]. 药学研究,2014.
APA	Xing, Ruijun,Liu, Gang,Zhu, Jinghan,Hou, Yanglong,&Chen, Xiaoyuan.(2014).Functional Magnetic Nanoparticles for Non-Viral Gene Delivery and MR Imaging.药学研究.
MLA	Xing, Ruijun,et al."Functional Magnetic Nanoparticles for Non-Viral Gene Delivery and MR Imaging".药学研究 (2014).