Influence of radiation crosslinked carboxymethyl-chitosan/gelatin   hydrogel on cutaneous wound healing

doi:10.1016/j.msec.2013.07.044

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	Influence of radiation crosslinked carboxymethyl-chitosan/gelatin hydrogel on cutaneous wound healing
	Huang, Xin ; Zhang, Yaqing ; Zhang, Xiangmei ; Xu, Ling ; Chen, Xin ; Wei, Shicheng
刊名	materials science engineering c materials for biological applications
	2013
关键词	Protein/polysaccharide blends Biodegradable gels Irradiation crosslinking Biocompatibility Wound healing TISSUE ENGINEERING APPLICATIONS GELATIN SKIN REPAIR FIBROBLASTS DRESSINGS SCAFFOLD REGENERATION INFLAMMATION DERIVATIVES
DOI	10.1016/j.msec.2013.07.044
英文摘要	A series of carboxymethyl chitosan (CM-chitosan) and gelatin hydrogels were prepared by radiation crosslinking. A pre-clinical study was performed by implantation model and full-thickness cutaneous wound model in Sprague-Dawley rats to preliminarily evaluate the biocompatibility, biodegradability and effects on healing. In the implantation test, as a component of the hydrogels, CM-chitosan showed a positive effect on promoting cell proliferation and neovascularization, while gelatin was efficient to stabilize the structure and prolong the degradation time. To evaluate the function on wound healing, the hydrogels were applied to the relatively large full-thickness cutaneous wounds (Phi 3.0 cm). Compared with the control groups, the hydrogel group showed significantly higher percentage of wound closure on days 9, 12 and 15 postoperatively, which was consistent with the significantly thicker granulation tissue on days 3 and 6. All results apparently revealed that the radiation crosslinked CM-chitosan/Gelatin hydrogels could induce granulation tissue formation and accelerate the wound healing. (C) 2013 Elsevier B.V. All rights reserved.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000327686900043&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Materials Science, Biomaterials; SCI(E); EI; PubMed; 10; ARTICLE; 8; 4816-4824; 33
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/153877]
专题	工学院
推荐引用方式 GB/T 7714	Huang, Xin,Zhang, Yaqing,Zhang, Xiangmei,et al. Influence of radiation crosslinked carboxymethyl-chitosan/gelatin hydrogel on cutaneous wound healing[J]. materials science engineering c materials for biological applications,2013.
APA	Huang, Xin,Zhang, Yaqing,Zhang, Xiangmei,Xu, Ling,Chen, Xin,&Wei, Shicheng.(2013).Influence of radiation crosslinked carboxymethyl-chitosan/gelatin hydrogel on cutaneous wound healing.materials science engineering c materials for biological applications.
MLA	Huang, Xin,et al."Influence of radiation crosslinked carboxymethyl-chitosan/gelatin hydrogel on cutaneous wound healing".materials science engineering c materials for biological applications (2013).