Prussian blue coated gold nanoparticles for simultaneous   photoacoustic/CT bimodal imaging and photothermal ablation of cancer

doi:10.1016/j.biomaterials.2014.04.005

CORC > 北京大学 > 工学院

	Prussian blue coated gold nanoparticles for simultaneous photoacoustic/CT bimodal imaging and photothermal ablation of cancer
	Jing, Lijia ; Liang, Xiaolong ; Deng, Zijian ; Feng, Shanshan ; Li, Xiaoda ; Huang, Maomao ; Li, Changhui ; Dai, Zhifei
刊名	biomaterials
	2014
关键词	Prussian blue Au nanoparticles X-ray computed tomography Photoacoustic imaging Photothermal therapy RAY COMPUTED-TOMOGRAPHY WALLED CARBON NANOTUBES IN-VIVO CONTRAST AGENT THERAPY NANOCAGES RESONANCE CELLS NANORODS GRAPHENE
DOI	10.1016/j.biomaterials.2014.04.005
英文摘要	The combination of CT imaging and photoacoustic (PA) imaging represents not only high resolution and ease of forming 3D visual image for locating tissues of interest, but also good soft tissue contrast and excellent high sensitivity, which is very beneficial to the precise guidance for photothermal therapy (PIT). The near infrared (NIR) absorbing Au nanostructures take advantages to operate as a CT contrast agent due to high absorption coefficient of X-ray and outstanding biocompatibility, but show obvious deficiency for PA imaging and PTT because of low photostability. Attacking this problem head on, the Au nanoparticles (NPs) were coated with Prussian blue (PB) which is a typical FDA-approved drug in clinic for safe and effective treatment of radioactive exposure. The obtained core/shell NPs of Au@PB NPs of 17.8 +/- 2.3 nm were found to be an excellent photoabsorbing agent for both PIT and PA imaging due to high photostability and high molar extinction coefficient in NIR region. Their gold core of 9.1 +/- 0.64 nm ensured a remarkable contrast enhancement for CT imaging. Through a one-time treatment of NIR laser irradiation after intravenous injection of Au@PB NPs, 100 mm(3) sized tumors in nude mice could be completely ablated without recurrence. Such versatile nanoparticles integrating effective cancer diagnosis with noninvasive therapy might bring opportunities to future cancer therapy. (C) 2014 Elsevier Ltd. All rights reserved.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000336694700018&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Engineering, Biomedical; Materials Science, Biomaterials; SCI(E); EI; PubMed; 38; ARTICLE; zhifei.dai@163.com; 22; 5814-5821; 35
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/153848]
专题	工学院
推荐引用方式 GB/T 7714	Jing, Lijia,Liang, Xiaolong,Deng, Zijian,et al. Prussian blue coated gold nanoparticles for simultaneous photoacoustic/CT bimodal imaging and photothermal ablation of cancer[J]. biomaterials,2014.
APA	Jing, Lijia.,Liang, Xiaolong.,Deng, Zijian.,Feng, Shanshan.,Li, Xiaoda.,...&Dai, Zhifei.(2014).Prussian blue coated gold nanoparticles for simultaneous photoacoustic/CT bimodal imaging and photothermal ablation of cancer.biomaterials.
MLA	Jing, Lijia,et al."Prussian blue coated gold nanoparticles for simultaneous photoacoustic/CT bimodal imaging and photothermal ablation of cancer".biomaterials (2014).