Controllability and observability of Boolean networks arising from   biology

doi:10.1063/1.4907708

CORC > 北京大学 > 工学院

	Controllability and observability of Boolean networks arising from biology
	Li, Rui ; Yang, Meng ; Chu, Tianguang
刊名	chaos
	2015
关键词	GENETIC REGULATORY NETWORKS COMPLEX NETWORKS POLYNOMIAL SYSTEMS CONTROL PROFILES DISCRETE MODELS TIME DELAYS SYNCHRONIZATION ROBUSTNESS EVOLUTION STABILIZATION
DOI	10.1063/1.4907708
英文摘要	Boolean networks are currently receiving considerable attention as a computational scheme for system level analysis and modeling of biological systems. Studying control-related problems in Boolean networks may reveal new insights into the intrinsic control in complex biological systems and enable us to develop strategies for manipulating biological systems using exogenous inputs. This paper considers controllability and observability of Boolean biological networks. We propose a new approach, which draws from the rich theory of symbolic computation, to solve the problems. Consequently, simple necessary and sufficient conditions for reachability, controllability, and observability are obtained, and algorithmic tests for controllability and observability which are based on the Grobner basis method are presented. As practical applications, we apply the proposed approach to several different biological systems, namely, the mammalian cell-cycle network, the T-cell activation network, the large granular lymphocyte survival signaling network, and the Drosophila segment polarity network, gaining novel insights into the control and/or monitoring of the specific biological systems. (C) 2015 AIP Publishing LLC.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000350547100004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Mathematics, Applied; Physics, Mathematical; SCI(E); PubMed; 5; ARTICLE; chutg@pku.edu.cn; 2; 023104; 25
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/153791]
专题	工学院
推荐引用方式 GB/T 7714	Li, Rui,Yang, Meng,Chu, Tianguang. Controllability and observability of Boolean networks arising from biology[J]. chaos,2015.
APA	Li, Rui,Yang, Meng,&Chu, Tianguang.(2015).Controllability and observability of Boolean networks arising from biology.chaos.
MLA	Li, Rui,et al."Controllability and observability of Boolean networks arising from biology".chaos (2015).