Measurement of temperature-dependent diffusion coefficients using a   confocal Raman microscope with microfluidic chips considering   laser-induced heating effect

doi:10.1016/j.aca.2010.03.061

CORC > 北京大学 > 软件与微电子学院

	Measurement of temperature-dependent diffusion coefficients using a confocal Raman microscope with microfluidic chips considering laser-induced heating effect
	Lin, Ying ; Yu, Xinhai ; Wang, Zhenyu ; Tu, Shan-Tung ; Wang, Zhengdong
刊名	analytica chimica acta
	2010
关键词	Temperature-dependent diffusion coefficient Raman microscope Microfluidic chip Laser-induced heating MICROCHANNEL SPECTROSCOPY DENSITIES CHANNELS DEVICES
DOI	10.1016/j.aca.2010.03.061
英文摘要	Conventional methods for measuring diffusion coefficients (D) are complex and time consuming. This study presents a method for the continuous measurement of temperature-dependent diffusion coefficients using a confocal Raman microscope with microfluidic chips. Concentration information was collected by a Raman microscope to extract D values. An isothermal diffusion process at various temperatures was ensured by coupling the silicon-based microfluidic chip with an isothermal plate. In the simple silicon/glass chip, the heating effect induced by a Raman laser was observed to contribute to abnormally high D values. To eliminate the heating effect, a 200 nm-thick aluminum (Al) reflection film was used to coat the channel bottom. The Al film substantially reduced absorption of laser power, thus ensuring precise D values in excellent agreement with literature data. Other potential methods to eliminate the heating effect were also evaluated by computational fluid dynamics (CFD) simulations and were found impractical for implementation. Consequently, this method for the continuous measurement of temperature-dependent diffusion coefficients is proven to be accurate, efficient, and reliable. (C) 2010 Elsevier B.V. All rights reserved.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000278152500013&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Chemistry, Analytical; SCI(E); EI; 9; ARTICLE; 1-2; 103-112; 667
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/244435]
专题	软件与微电子学院
推荐引用方式 GB/T 7714	Lin, Ying,Yu, Xinhai,Wang, Zhenyu,et al. Measurement of temperature-dependent diffusion coefficients using a confocal Raman microscope with microfluidic chips considering laser-induced heating effect[J]. analytica chimica acta,2010.
APA	Lin, Ying,Yu, Xinhai,Wang, Zhenyu,Tu, Shan-Tung,&Wang, Zhengdong.(2010).Measurement of temperature-dependent diffusion coefficients using a confocal Raman microscope with microfluidic chips considering laser-induced heating effect.analytica chimica acta.
MLA	Lin, Ying,et al."Measurement of temperature-dependent diffusion coefficients using a confocal Raman microscope with microfluidic chips considering laser-induced heating effect".analytica chimica acta (2010).