Urinary Metabolites of Polycyclic Aromatic Hydrocarbons and the Association with Lipid Peroxidation: A Biomarker-Based Study between Los Angeles and Beijing | |
Lin, Yan ; Qiu, Xinghua ; Yu, Nu ; Yang, Qiaoyun ; Araujo, Jesus A. ; Zhu, Yifang | |
刊名 | ENVIRONMENTAL SCIENCE & TECHNOLOGY |
2016 | |
关键词 | COKE-OVEN WORKERS LUNG-CANCER RISK OXIDATIVE STRESS ENVIRONMENTAL EXPOSURE AIR-POLLUTION PAH EXPOSURE NORTH CHINA NAPHTHALENE POPULATION ENZYMES |
DOI | 10.1021/acs.est.5b04629 |
英文摘要 | Air pollution is among the top threats to human health in China. As air toxicants, polycyclic aromatic hydrocarbons (PAHs) could bring significant risks to population; however, the exposure to PAHs in China and its health impact are not fully understood. In 2012, a summer exchange program allowed 10 students to travel from Los Angeles to Beijing and stay there for 10 weeks. Based on the program, this study investigated the difference in urinary concentration of 12 hydroxylated-PAHs (Sigma 12OH-PAHs) and malondialdehyde (MDA) between the two cities. The median concentration of Sigma 12OH-PAHs in Beijing (14.1 mu g g(-1) creatinine) was significantly higher than that in Los Angeles (5.78 mu g g(-1) creatinine), indicating a higher exposure in Beijing. The ratios of homogeneous OH-PAHs (e.g., 1-/2-OH-NAP) changed significantly between the two cities (p < 0.01), which might suggest a potential alteration in metabolism subsequent to exposure. A significant association between Sigma 12OH-PAHs and MDA (p < 0.01) was observed, with the association varying between the two cities. This study suggests that exposure to PAHs might be linked to metabolism alteration and calls for future studies to investigate the role this possible alteration played in the health effects of PAHs exposure.; National Institute of Environmental Health Sciences (NIEHS) [1R21ES024560]; National Natural Science Foundation of China [21322705, 41421064, 21190051]; Top-Notch Young Talents Program of China; Collaborative Innovation Center for Regional Environmental Quality; Chinese Scholarship Council; SCI(E); EI; PubMed; ARTICLE; xhqiu@pku.edu.cn; yifang@ucla.edu; 7; 3738-3745; 50 |
语种 | 英语 |
内容类型 | 期刊论文 |
源URL | [http://ir.pku.edu.cn/handle/20.500.11897/434758] |
专题 | 环境科学与工程学院 |
推荐引用方式 GB/T 7714 | Lin, Yan,Qiu, Xinghua,Yu, Nu,et al. Urinary Metabolites of Polycyclic Aromatic Hydrocarbons and the Association with Lipid Peroxidation: A Biomarker-Based Study between Los Angeles and Beijing[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2016. |
APA | Lin, Yan,Qiu, Xinghua,Yu, Nu,Yang, Qiaoyun,Araujo, Jesus A.,&Zhu, Yifang.(2016).Urinary Metabolites of Polycyclic Aromatic Hydrocarbons and the Association with Lipid Peroxidation: A Biomarker-Based Study between Los Angeles and Beijing.ENVIRONMENTAL SCIENCE & TECHNOLOGY. |
MLA | Lin, Yan,et al."Urinary Metabolites of Polycyclic Aromatic Hydrocarbons and the Association with Lipid Peroxidation: A Biomarker-Based Study between Los Angeles and Beijing".ENVIRONMENTAL SCIENCE & TECHNOLOGY (2016). |
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