Association Between Changes in Exposure to Air Pollution and Biomarkers   of Oxidative Stress in Children Before and During the Beijing Olympics

doi:10.1093/aje/kwu327

CORC > 北京大学 > 环境科学与工程学院

	Association Between Changes in Exposure to Air Pollution and Biomarkers of Oxidative Stress in Children Before and During the Beijing Olympics
	Lin, Weiwei ; Zhu, Tong ; Xue, Tao ; Peng, Wei ; Brunekreef, Bert ; Gehring, Ulrike ; Huang, Wei ; Hu, Min ; Zhang, Yuanhang ; Tang, Xiaoyan
刊名	AMERICAN JOURNAL OF EPIDEMIOLOGY
	2015
关键词	air pollution black carbon children 8-oxo-7,8-dihydro-2 &apos intervention malondialdehyde oxidative stress particulate matter HEALTHY-YOUNG ADULTS DNA-DAMAGE URINARY 8-HYDROXY-2&apos BLACK CARBON INFLAMMATION POLLUTANTS QUALITY DISEASE MARKER CHINA -deoxyguanosine -DEOXYGUANOSINE
DOI	10.1093/aje/kwu327
英文摘要	It is not known whether exposure to air pollutants causes systemic oxidative stress in children. We investigated the association between exposure to air pollution and biomarkers of oxidative stress in relation to a governmental air quality intervention implemented during the 2008 Beijing Olympic Games. We studied 36 schoolchildren during 5 time periods before and during the Olympic Games in Beijing (June 2007-September 2008). The oxidative stress biomarkers 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and malondialdehyde were measured in urine samples collected daily during each period. Generalized estimating equations were used to examine the relationship between repeated biomarker measurements and ambient air pollutant levels. During the Olympic intervention period, substantial reductions in air pollution (-19% to -72%), urinary 8-oxodG concentrations (-37.4%; 95% confidence interval: -53.5, -15.7), and urinary malondialdehyde concentrations (-25.3%; 95% confidence interval: -34.3, -15.1) were found. Malondialdehyde and 8-oxodG were significantly associated with concentrations of black carbon, fine particulate matter with an aerodynamic with diameter less than 2.5 mu m, sulfur dioxide, nitrogen dioxide, and carbon monoxide. Biomarker changes per each interquartile-range increase in pollutants were largest at lag 0 or lag 1. In a 2-pollutant model, the most robust associations were for black carbon. These findings suggest that exposure to black carbon leads to systemic oxidative stress in children.; National Natural Science Foundation Committee of China [21190051, 41121004, 20637020]; Chinese Ministry of Science and Technology [2008AA062503]; SCI(E); ARTICLE; tzhu@pku.edu.cn; 8; 575-583; 181
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/420457]
专题	环境科学与工程学院
推荐引用方式 GB/T 7714	Lin, Weiwei,Zhu, Tong,Xue, Tao,et al. Association Between Changes in Exposure to Air Pollution and Biomarkers of Oxidative Stress in Children Before and During the Beijing Olympics[J]. AMERICAN JOURNAL OF EPIDEMIOLOGY,2015.
APA	Lin, Weiwei.,Zhu, Tong.,Xue, Tao.,Peng, Wei.,Brunekreef, Bert.,...&Tang, Xiaoyan.(2015).Association Between Changes in Exposure to Air Pollution and Biomarkers of Oxidative Stress in Children Before and During the Beijing Olympics.AMERICAN JOURNAL OF EPIDEMIOLOGY.
MLA	Lin, Weiwei,et al."Association Between Changes in Exposure to Air Pollution and Biomarkers of Oxidative Stress in Children Before and During the Beijing Olympics".AMERICAN JOURNAL OF EPIDEMIOLOGY (2015).