Characterizing and biological monitoring of polycyclic aromatic   hydrocarbons in exposures to diesel exhaust

doi:10.1021/es062863j

CORC > 北京大学 > 环境科学与工程学院

	Characterizing and biological monitoring of polycyclic aromatic hydrocarbons in exposures to diesel exhaust
	Huang, Wei ; Smith, Thomas J. ; Ngo, Long ; Wang, Tong ; Chen, Hongqiao ; Wu, Fanggu ; Herrick, Robert F. ; Christiani, David C. ; Ding, Hui
刊名	environmental science technology
	2007
关键词	COKE-OVEN WORKERS URINARY 1-HYDROXYPYRENE OCCUPATIONAL-EXPOSURE INDICATOR EXCRETION CARCINOGENESIS BIOMARKERS AMBIENT PLANT PAHS
DOI	10.1021/es062863j
英文摘要	Polycyclic aromatic hydrocarbons (PAHs) are one of the most important and carcinogenic components in diesel exhaust (DE). Therefore, ambient PAHs concentrations were measured and characterized forwork areas in a locomotive engine inspection plant. Pre- and post-shift urine samples and concurrent air samples were collected on 17 workers to measure the concentration of urinary 1-hydroxypyrene (1-OHP) a metabolite of pyrene. Increased urinary 1-OHP concentrations were observed over at least three consecutive sampling days. The biological kinetics of pyrene metabolism was studied with a one-compartment pharmokinetic model. The conversion rate and elimination rate of 1-0HP were estimated using nonlinear mixedeffects model, and validated with multiple nonlinear regression models by assessing the pattern of elimination rates of each worker separately. Urinary 1-OHP was confirmed to be a sensitive marker of PAHs exposure with mean halflife of 29 h in this population of Chinese workers. The study results would be beneficial to future occupational and environmental studies of PAH exposure.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000245892900017&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Engineering, Environmental; Environmental Sciences; SCI(E); EI; 28; ARTICLE; 8; 2711-2716; 41
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/251490]
专题	环境科学与工程学院
推荐引用方式 GB/T 7714	Huang, Wei,Smith, Thomas J.,Ngo, Long,et al. Characterizing and biological monitoring of polycyclic aromatic hydrocarbons in exposures to diesel exhaust[J]. environmental science technology,2007.
APA	Huang, Wei.,Smith, Thomas J..,Ngo, Long.,Wang, Tong.,Chen, Hongqiao.,...&Ding, Hui.(2007).Characterizing and biological monitoring of polycyclic aromatic hydrocarbons in exposures to diesel exhaust.environmental science technology.
MLA	Huang, Wei,et al."Characterizing and biological monitoring of polycyclic aromatic hydrocarbons in exposures to diesel exhaust".environmental science technology (2007).