PM2.5 Constituents and Oxidative DNA Damage in Humans

doi:10.1021/es803337c

CORC > 北京大学 > 环境科学与工程学院

	PM2.5 Constituents and Oxidative DNA Damage in Humans
	Wei, Yongjie ; Han, In-Kyu ; Shao, Min ; Hu, Min ; Zhang, Junfeng ; Tang, Xiaoyan
刊名	environmental science technology
	2009
关键词	AIRBORNE PARTICULATE MATTER POLYCYCLIC AROMATIC-HYDROCARBONS OCCUPATIONALLY EXPOSED WORKERS DIESEL EXHAUST PARTICLES AIRWAY EPITHELIAL-CELLS WHITE BLOOD-CELLS TRANSITION-METALS URINARY 8-HYDROXY-2&apos ORGANIC-COMPOUNDS STRESS -DEOXYGUANOSINE
DOI	10.1021/es803337c
英文摘要	Previous studies suggested that certain constituents of ambient PM2.5 can induce or increase oxidative stress in biological systems. The present study is designed to examine whether exposure to traffic generated particles increases the burden of oxidative stress in humans and to identify specific PM2.5 constituents responsible for pollution-induced oxidative stress. We recruited two nonsmoking security guards who worked at a university campus gate by a heavily trafficked road. Pre- and post-workshift spot urines were collected on each of the 29 days of measurement. Concentrations of PM2.5 Mass and 126 chemical species were measured at the worksite and a campus background site simultaneously. Urine samples were analyzed for 8-hydroxy-2'-deoxyguanosine (8-OHdG). Factor analysis and linear mixed-effects regression models were used in statistical analyses. Three clusters of PM2.5 species were identified, including PAHs, metals, and polar organic compounds. Urinary concentrations of 8-OHdG increased by >3 times following an eight-hour workshift in participants. Pre-workshift urinary concentrations of 8-OHdG were-associated with PM2.5 concentrations at the background site. Post-workshift 8-OHdG concentrations were significantly and positively associated with PM2.5 mass, PAHs, and metals, but not polar organic species, measured at the worksite. Our findings provide direct evidence in humans that PM compositions are important in increasing oxidative stress burdens. Our results support that PAHs and metals are biologically active constituents of PM2.5 with regards to the induction of oxidative DNA damages in the human body.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000267435500024&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Engineering, Environmental; Environmental Sciences; SCI(E); EI; PubMed; 46; ARTICLE; 13; 4757-4762; 43
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/158929]
专题	环境科学与工程学院
推荐引用方式 GB/T 7714	Wei, Yongjie,Han, In-Kyu,Shao, Min,et al. PM2.5 Constituents and Oxidative DNA Damage in Humans[J]. environmental science technology,2009.
APA	Wei, Yongjie,Han, In-Kyu,Shao, Min,Hu, Min,Zhang, Junfeng,&Tang, Xiaoyan.(2009).PM2.5 Constituents and Oxidative DNA Damage in Humans.environmental science technology.
MLA	Wei, Yongjie,et al."PM2.5 Constituents and Oxidative DNA Damage in Humans".environmental science technology (2009).