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	Alpha/beta-hydrolase domain-containing 6(ABHD6) negatively regulates the surface delivery and synaptic function of AMPA receptors; Alpha/beta-hydrolase domain-containing 6(ABHD6) negatively regulates the surface delivery and synaptic function of AMPA receptors
	Mengping Wei ; Jian Zhang ; Moye Jia ; Chaojuan Yang ; Yunlong Pan ; Shuaiqi Li ; Yiwen Luo ; Junyuan Zheng ; Jianguo Ji ; Jianguo Chen ; Xinli Hu ; Jingwei Xiong ; Yun Shi ; Chen Zhang
	2016
关键词	ABHD6 AMPA receptor synapses receptor trafficking ABHD6 AMPA receptor synapses receptor trafficking
英文摘要	In the brain, a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid(AMPA)-type glutamate receptors are major postsynaptic receptors at excitatory synapses that mediate fast neurotransmission and synaptic plasticity. α/β-Hydrolase domain containing 6(ABHD6), a monoacylglycerol lipase, was previously found to be a component of AMPA receptor macromolecular complexes, but its physiological significance in the function of AMPA receptors(AMPARs) has remained unclear. The present study showed that overexpression of ABHD6 in neurons drastically reduced excitatory neurotransmission mediated by AMPA but not by N-methylD-aspartate receptors(NMDARs) at excitatory synapses. Inactivation of ABHD6 expression in neurons by either CRISPR/Cas9 or sh RNA knockdown methods significantly increased excitatory neurotransmission at excitatory synapses. Interestingly, overexpression of ABHD6 reduced glutamate-induced currents and the surface expression of GluA1 in HEK293 T cells expressing GluA1 and stargazin, suggesting a direct func...; In the brain, a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid(AMPA)-type glutamate receptors are major postsynaptic receptors at excitatory synapses that mediate fast neurotransmission and synaptic plasticity. α/β-Hydrolase domain containing 6(ABHD6), a monoacylglycerol lipase, was previously found to be a component of AMPA receptor macromolecular complexes, but its physiological significance in the function of AMPA receptors(AMPARs) has remained unclear. The present study showed that overexpression o; 中国神经科学学会; 2
语种	英语
出处	第九届海内外华人神经科学家研讨会
内容类型	其他
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/479927]
专题	心理与认知科学学院
推荐引用方式 GB/T 7714	Mengping Wei,Jian Zhang,Moye Jia,et al. Alpha/beta-hydrolase domain-containing 6(ABHD6) negatively regulates the surface delivery and synaptic function of AMPA receptors, Alpha/beta-hydrolase domain-containing 6(ABHD6) negatively regulates the surface delivery and synaptic function of AMPA receptors. 2016-01-01.

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