Mapping the genetic variation of executive attention onto brain activity | |
Fan, J ; Fossella, J ; Sommer, T ; Wu, YH ; Posner, MI | |
刊名 | proceedings of the national academy of sciences of the united states of america
![]() |
2003 | |
关键词 | ANTERIOR CINGULATE CORTEX DOPAMINE POLYMORPHISM INNERVATION CONFLICT PROMOTER CHILDREN FMRI |
DOI | 10.1073/pnas.0732088100 |
英文摘要 | Brain imaging data have repeatedly shown that the anterior cingulate cortex is an important node in the brain network mediating conflict. We previously reported that polymorphisms in dopamine receptor (DRD4) and monoamine oxidase A (MAOA) genes showed significant associations with efficiency of handling conflict as measured by reaction time differences in the Attention Network Test (ANT). To examine whether this genetic variation might contribute to differences in brain activation within the anterior cingulate cortex, we genotyped 16 subjects for the DRD4 and MAOA genes who had been scanned during the ANT. In each of the two genes previously associated with more efficient handling of conflict in reaction time experiments, we found a polymorphism in which persons with the allele associated with better behavioral performance showed significantly more activation in the anterior cingulate while performing the ANT than those with the allele associated with worse performance. The results demonstrate how genetic differences among individuals can be linked to individual differences in neuromodulators and in the efficiency of the operation of an appropriate attentional network.; Multidisciplinary Sciences; SCI(E); SSCI; 214; ARTICLE; 12; 7406-7411; 100 |
语种 | 英语 |
内容类型 | 期刊论文 |
源URL | [http://ir.pku.edu.cn/handle/20.500.11897/401743] ![]() |
专题 | 心理与认知科学学院 |
推荐引用方式 GB/T 7714 | Fan, J,Fossella, J,Sommer, T,et al. Mapping the genetic variation of executive attention onto brain activity[J]. proceedings of the national academy of sciences of the united states of america,2003. |
APA | Fan, J,Fossella, J,Sommer, T,Wu, YH,&Posner, MI.(2003).Mapping the genetic variation of executive attention onto brain activity.proceedings of the national academy of sciences of the united states of america. |
MLA | Fan, J,et al."Mapping the genetic variation of executive attention onto brain activity".proceedings of the national academy of sciences of the united states of america (2003). |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论