Mapping the genetic variation of executive attention onto brain activity

doi:10.1073/pnas.0732088100

CORC > 北京大学 > 心理与认知科学学院

	Mapping the genetic variation of executive attention onto brain activity
	Fan, J ; Fossella, J ; Sommer, T ; Wu, YH ; Posner, MI
刊名	proceedings of the national academy of sciences of the united states of america
	2003
关键词	ANTERIOR CINGULATE CORTEX DOPAMINE POLYMORPHISM INNERVATION CONFLICT PROMOTER CHILDREN FMRI
DOI	10.1073/pnas.0732088100
英文摘要	Brain imaging data have repeatedly shown that the anterior cingulate cortex is an important node in the brain network mediating conflict. We previously reported that polymorphisms in dopamine receptor (DRD4) and monoamine oxidase A (MAOA) genes showed significant associations with efficiency of handling conflict as measured by reaction time differences in the Attention Network Test (ANT). To examine whether this genetic variation might contribute to differences in brain activation within the anterior cingulate cortex, we genotyped 16 subjects for the DRD4 and MAOA genes who had been scanned during the ANT. In each of the two genes previously associated with more efficient handling of conflict in reaction time experiments, we found a polymorphism in which persons with the allele associated with better behavioral performance showed significantly more activation in the anterior cingulate while performing the ANT than those with the allele associated with worse performance. The results demonstrate how genetic differences among individuals can be linked to individual differences in neuromodulators and in the efficiency of the operation of an appropriate attentional network.; Multidisciplinary Sciences; SCI(E); SSCI; 214; ARTICLE; 12; 7406-7411; 100
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/401743]
专题	心理与认知科学学院
推荐引用方式 GB/T 7714	Fan, J,Fossella, J,Sommer, T,et al. Mapping the genetic variation of executive attention onto brain activity[J]. proceedings of the national academy of sciences of the united states of america,2003.
APA	Fan, J,Fossella, J,Sommer, T,Wu, YH,&Posner, MI.(2003).Mapping the genetic variation of executive attention onto brain activity.proceedings of the national academy of sciences of the united states of america.
MLA	Fan, J,et al."Mapping the genetic variation of executive attention onto brain activity".proceedings of the national academy of sciences of the united states of america (2003).