Protein Kinase DI-Dependent Phosphorylation of Dopamine DI Receptor   Regulates Cocaine-Induced Behavioral Responses

doi:10.1038/npp.2013.341

CORC > 北京大学 > 心理与认知科学学院

	Protein Kinase DI-Dependent Phosphorylation of Dopamine DI Receptor Regulates Cocaine-Induced Behavioral Responses
	Wang, Ning ; Su, Ping ; Zhang, Ying ; Lu, Jie ; Xing, Baoming ; Kang, Kai ; Li, Wenqi ; Wang, Yun
刊名	neuropsychopharmacology
	2014
关键词	cocaine addiction protein kinase DI dopamine DI receptor phosphorylation conditioned place preference locomotor activity AGONIST-INDUCED DESENSITIZATION NUCLEUS-ACCUMBENS SHELL NEUROBLASTOMA-CELLS D-1 RECEPTOR D1 ACTIVATION NEURONS TRAFFICKING TRANSPORTER ADDICTION
DOI	10.1038/npp.2013.341
英文摘要	The dopamine (DA) DI receptor (DIR) is critically involved in reward and drug addiction. Phosphorylation-mediated desensitization or internalization of DIR has been extensively investigated. However, the potential for upregulation of DIR function through phosphorylation remains to be determined. Here we report that acute cocaine exposure induces protein kinase DI (PKD I) activation in the rat striatum, and knockdown of PKDI in the rat dorsal striatum attenuates cocaine-induced locomotor hyperactivity. Moreover, PKD I -mediated phosphorylation of serine 421 (S42I) of DIR promotes surface localization of D1R and enhances downstream extracellular signal-regulated kinase signaling in DIR-transfected HEK 293 cells. Importantly, injection of the peptide Tat-S421, an engineered Tat fusion-peptide targeting S42I (Tat-S421), into the rat dorsal striatum inhibits cocaine-induced locomotor hyperactivity and injection of Tat-S421 into the rat hippocampus or the shell of the nucleus accumbens (NAc) also inhibits cocaine-induced conditioned place preference (CPP). However, injection of Tat-S421 into the rat NAc shell does not establish CPP by itself and injection of Tat-S421 into the hippocampus does not influence spatial learning and memory. Thus, targeting S421 of DIR represents a promising strategy for the development of pharmacotherapeutic treatments for drug addiction and other disorders that result from DA imbalances.; Neurosciences; Pharmacology & Pharmacy; Psychiatry; SCI(E); PubMed; 1; ARTICLE; wangy66@bjmu.edu.cn; 5; 1290-1301; 39
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/342645]
专题	心理与认知科学学院
推荐引用方式 GB/T 7714	Wang, Ning,Su, Ping,Zhang, Ying,et al. Protein Kinase DI-Dependent Phosphorylation of Dopamine DI Receptor Regulates Cocaine-Induced Behavioral Responses[J]. neuropsychopharmacology,2014.
APA	Wang, Ning.,Su, Ping.,Zhang, Ying.,Lu, Jie.,Xing, Baoming.,...&Wang, Yun.(2014).Protein Kinase DI-Dependent Phosphorylation of Dopamine DI Receptor Regulates Cocaine-Induced Behavioral Responses.neuropsychopharmacology.
MLA	Wang, Ning,et al."Protein Kinase DI-Dependent Phosphorylation of Dopamine DI Receptor Regulates Cocaine-Induced Behavioral Responses".neuropsychopharmacology (2014).