Brain stem circuits mediating prepulse inhibition of the startle reflex

doi:10.1007/s002130100794

CORC > 北京大学 > 心理与认知科学学院

	Brain stem circuits mediating prepulse inhibition of the startle reflex
	Fendt, M ; Li, L ; Yeomans, JS
刊名	psychopharmacology
	2001
关键词	acetylcholine attention caudal pontine reticular nucleus GABA inferior colliculus laterodorsal tegmental nucleus prepulse inhibition peduculopontine tegmental nucleus sensorimotor gating startle response substantia nigra pars reticulata superior colliculus PEDUNCULOPONTINE TEGMENTAL NUCLEUS PONTINE RETICULAR-FORMATION RATS INFERIOR COLLICULUS ACOUSTIC STARTLE SUPERIOR COLLICULUS ELECTRICAL-STIMULATION CHOLINERGIC MODULATION ATTENTIONAL PROCESSES EYEBLINK MODIFICATION BINAURAL RESPONSES
DOI	10.1007/s002130100794
英文摘要	Rationale: Prepulse inhibition (PPI) of the startle reflex occurs when brief. non-startling tactile, acoustic or visual stimuli are presented 20-500 ms before the startling stimulus. Objective: To review information about PPI-mediating brain stem circuits and transmitters, and their functions. Results: Midbrain systems are most critical for the fast relay of these PPI stimuli. Acoustic prepulses for PPI are relayed through the inferior colliculus (IC). The superior colliculus (SC) is important for acoustic PPI, and may be important for the mediation of tactile and visual prepulses. This collicular activation for PPI is quickly relayed through the pedunculopontine tegmental nucleus (PPTg), with lesser contributions to PPI from the laterodorsal tegmental nucleus (LDTg) and substantia nigra, pars reticulata (SNR). The transient activation of midbrain nuclei by PPI stimuli is converted into long-lasting inhibition of the giant neurons of the caudal pontine reticular nucleus (PnC). We propose that muscarinic and GABAB inhibitory receptors (both metabotropic receptors) on PnC giant neurons combine to produce the long-lasting inhibition of startle. Activation of mesopontine cholinergic neurons leads to cortical arousal, turning and exploratory approach responses. Conclusion: PPI is mediated by a circuit involving the IC, SC, PPTg, LDTg, SNR and NC. By reducing startle, PPI allows the execution of approach responses and perceptual processing following salient stimuli.; Neurosciences; Pharmacology & Pharmacy; Psychiatry; SCI(E); 179; REVIEW; 2-3; 216-224; 156
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/258126]
专题	心理与认知科学学院
推荐引用方式 GB/T 7714	Fendt, M,Li, L,Yeomans, JS. Brain stem circuits mediating prepulse inhibition of the startle reflex[J]. psychopharmacology,2001.
APA	Fendt, M,Li, L,&Yeomans, JS.(2001).Brain stem circuits mediating prepulse inhibition of the startle reflex.psychopharmacology.
MLA	Fendt, M,et al."Brain stem circuits mediating prepulse inhibition of the startle reflex".psychopharmacology (2001).