Isolation rearing induces social and emotional function abnormalities   and alters glutamate and neurodevelopment-related gene expression in   rats

doi:10.1016/j.pnpbp.2009.06.016

CORC > 北京大学 > 心理与认知科学学院

	Isolation rearing induces social and emotional function abnormalities and alters glutamate and neurodevelopment-related gene expression in rats
	Zhao, Xiaohong ; Sun, Lei ; Jia, Hongxiao ; Meng, Qingxuan ; Wu, Si ; Li, Nanxin ; He, Shuchang
刊名	神经与精神药理学和生物精神病学进展
	2009
关键词	Anxiety Glutamate Neurodevelopmental-related gene Social isolation Social recognition ISOLATION-REARED RATS MEDIAL PREFRONTAL CORTEX ELEVATED PLUS-MAZE PREPULSE INHIBITION NMDA RECEPTOR WISTAR RATS RECOGNITION DEFICITS ENVIRONMENT PLASTICITY
DOI	10.1016/j.pnpbp.2009.06.016
英文摘要	Isolation rearing induces various cognitive abnormalities such as reversal learning deficits and reduced prepulse inhibition in rats. However, there are few reports in the literature on its effects on social and emotional functions. In the current study we aimed to address these issues and demonstrated that isolation rearing induced aggression and impaired social recognition, produced moderate anxiogenic effects in the elevated-plus maze, and resulted in hyperactivity in a novel open field. We also found NR2A, NR2B, PSD-95 and SAP-102 mRNA expression were significantly up-regulated in the hippocampus while NR2B was down-regulated in prefrontal cortex in response to isolation rearing. This study advances the use of social isolation as an animal model for studying etiological mechanisms of various neuropsychiatric disorders. (C) 2009 Elsevier Inc. All rights reserved.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000270285500012&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry; SCI(E); 38; REVIEW; 7; 1173-1177; 33
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/246242]
专题	心理与认知科学学院
推荐引用方式 GB/T 7714	Zhao, Xiaohong,Sun, Lei,Jia, Hongxiao,et al. Isolation rearing induces social and emotional function abnormalities and alters glutamate and neurodevelopment-related gene expression in rats[J]. 神经与精神药理学和生物精神病学进展,2009.
APA	Zhao, Xiaohong.,Sun, Lei.,Jia, Hongxiao.,Meng, Qingxuan.,Wu, Si.,...&He, Shuchang.(2009).Isolation rearing induces social and emotional function abnormalities and alters glutamate and neurodevelopment-related gene expression in rats.神经与精神药理学和生物精神病学进展.
MLA	Zhao, Xiaohong,et al."Isolation rearing induces social and emotional function abnormalities and alters glutamate and neurodevelopment-related gene expression in rats".神经与精神药理学和生物精神病学进展 (2009).