Interactions of galanin and opiolds in nociceptive modulation in the   arcuate nucleus of hypothalamus in rats

doi:10.1016/j.regpep.2004.06.023

CORC > 北京大学 > 心理与认知科学学院

	Interactions of galanin and opiolds in nociceptive modulation in the arcuate nucleus of hypothalamus in rats
	Sun, YG ; Yu, LC
刊名	正规肽
	2005
关键词	antinociception galanin receptors galantide opioid receptors morphine RECEPTOR MESSENGER-RNA ENDOGENOUS BETA-ENDORPHIN PROOPIOMELANOCORTIN NEURONS MEDIOBASAL HYPOTHALAMUS PERIAQUEDUCTAL GREY SPINAL ANTINOCICEPTION MORPHINE BRAIN MONONEUROPATHY IMMUNOREACTIVITY
DOI	10.1016/j.regpep.2004.06.023
英文摘要	The fact that galanin, beta-endorphin and their receptors are present in the arcuate nucleus of hypothalamus (ARC), coupled with our previous observation that both beta-endorphin and galanin play antinociceptive roles in pain modulation in the ARC, made it of interest to study their interactions. The hindpaw withdrawal latency (HWL) in response to noxious thermal and mechanical stimulation was assessed by the hot-plate test and the Randall Selitto Test. We showed that the antinociceptive effect induced by intra-ARC injection of galanin was dose-dependently attenuated by the following intra-ARC injection of naloxone. Furthermore, intra-ARC administration of the selective mu-opioid receptor antagonist beta-funaltrexamine (beta-FNA) attenuated the increased HWL induced by intra-ARC injection of galanin in a dose-dependent manner, while the delta-opioid receptor antagonist naltrindole or the kappa-opioid receptor antagonist nor-binaltorphimine (nor-BNI) did not. Moreover, intra-ARC injection of a galanin receptor antagonist galantide attenuated intraperitoneal morphine-induced increases in HWLs. These results demonstrate that the antinociceptive effect of galanin was related to the opioid system, especially mu-opioid receptor was involved in, and that systemic morphine induced antinociception involves galanin in the ARC. (C) 2004 Elsevier B.V. All rights reserved.; Endocrinology & Metabolism; Physiology; SCI(E); PubMed; 0; ARTICLE; 1-3; 37-43; 124
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/199912]
专题	心理与认知科学学院
推荐引用方式 GB/T 7714	Sun, YG,Yu, LC. Interactions of galanin and opiolds in nociceptive modulation in the arcuate nucleus of hypothalamus in rats[J]. 正规肽,2005.
APA	Sun, YG,&Yu, LC.(2005).Interactions of galanin and opiolds in nociceptive modulation in the arcuate nucleus of hypothalamus in rats.正规肽.
MLA	Sun, YG,et al."Interactions of galanin and opiolds in nociceptive modulation in the arcuate nucleus of hypothalamus in rats".正规肽 (2005).