Glutamate and GABA(B) transmissions in lateral amygdala are involved in   startle-like electromyographic (EMG) potentiation caused by activation   of auditory thalamus

doi:10.1016/j.neulet.2004.10.035

CORC > 北京大学 > 心理与认知科学学院

	Glutamate and GABA(B) transmissions in lateral amygdala are involved in startle-like electromyographic (EMG) potentiation caused by activation of auditory thalamus
	He, SC ; Huang, J ; Wu, XH ; Li, L
刊名	神经科学快报
	2005
关键词	startle potentiation lateral amygdala nucleus medial geniculate nucleus auditory association cortex glutamate receptors GABA(B) receptors BLOCK CONDITIONED FEAR CENTRAL GRAY BLOCK ACOUSTIC STARTLE RETICULAR-FORMATION SYNAPTIC-TRANSMISSION BASOLATERAL AMYGDALA TEMPORAL CORTEX AMPA RECEPTORS DEEP LAYERS NUCLEUS
DOI	10.1016/j.neulet.2004.10.035
英文摘要	The lateral amygdala nucleus (LA) receives auditory inputs from both the auditory thalamus (media] geniculate nucleus, MGN) and auditory association cortex (AAC). These auditory inputs are closely linked with glutamate and GABA(B) receptors in the LA. The LA has intra-amygdaloid connections with the central amygdala nucleus, which mediates auditory fear potentiation of startle (AFPS) via pathways to the startle circuits. The purpose of the present study was to establish an electromyographic (EMG) model for studying AFPS-related neural transmissions in the LA. Hind-limb startle-like EMG responses to single-pulse electrical stimulation of the trigeminal nucleus (TN) were recorded in anesthetized rats. These EMG responses were enhanced by single-pulse sub-threshold electrical stimulation of the MGN when the MGN stimulus led the TN stimulus at short inter-stimulus intervals (ISI). However, the EMG responses were not affected by single-pulse sub-threshold electrical stimulation of the AAC. Bilateral injection of the glutamate antagonist, kynurenic acid, into the LA decreased both the EMG enhancement caused by MGN stimulation at short ISIs and EMG responses to combined TN and AAC stimulation across various ISIs. Moreover, bilateral injection of the GABAB antagonist, phaclofen, into the LA increased both EMG responses to combined TN and MGN stimulation across various ISIs, and EMG responses to combined TN and AAC stimulation at short ISIs. These results suggest that the auditory inputs to the LA from the MGN and those from the AAC are affected differently by glutamate and GABAB receptors in the LA, and play differential roles in modulating startle responses. (c) 2004 Elsevier Ireland Ltd. All rights reserved.; Neurosciences; SCI(E); PubMed; 3; ARTICLE; 2; 113-118; 374
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/199851]
专题	心理与认知科学学院信息科学技术学院
推荐引用方式 GB/T 7714	He, SC,Huang, J,Wu, XH,et al. Glutamate and GABA(B) transmissions in lateral amygdala are involved in startle-like electromyographic (EMG) potentiation caused by activation of auditory thalamus[J]. 神经科学快报,2005.
APA	He, SC,Huang, J,Wu, XH,&Li, L.(2005).Glutamate and GABA(B) transmissions in lateral amygdala are involved in startle-like electromyographic (EMG) potentiation caused by activation of auditory thalamus.神经科学快报.
MLA	He, SC,et al."Glutamate and GABA(B) transmissions in lateral amygdala are involved in startle-like electromyographic (EMG) potentiation caused by activation of auditory thalamus".神经科学快报 (2005).