Myosin Vb gene is associated with schizophrenia in Chinese Han   population

doi:10.1016/j.psychres.2013.02.026

CORC > 北京大学 > 心理与认知科学学院

	Myosin Vb gene is associated with schizophrenia in Chinese Han population
	Chen, Yaguang ; Tian, Lin ; Zhang, Fuquan ; Liu, Chenxing ; Lu, Tianlan ; Ruan, Yanyan ; Wang, Lifang ; Yan, Hao ; Yan, Jun ; Liu, Qi ; Zhang, Hongyan ; Ma, WenBin ; Yang, JianLi ; Li, KeQing ; Lv, LuXian ; Zhang, Dai ; Yue, Weihua
刊名	psychiatry research
	2013
关键词	AMPA receptor Glutamate Bipolar disorder Genetic association Polymorphism GENOME-WIDE ASSOCIATION BIPOLAR DISORDER GLUTAMATE HYPOTHESIS AMPA RECEPTORS EXPRESSION DISEASE LINKAGE VISUALIZATION METAANALYSIS BRAIN
DOI	10.1016/j.psychres.2013.02.026
英文摘要	Myosin Vb (MYO5B) has recently been implicated in the etiology of bipolar disorder in a genome-wide association study (GWAS). This gene is involved in amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor subunit glutamate receptor 1 (GluR1) recycling and plays an important role in the primary excitatory neurotransmission. Dysfunction of the brain glutamate system has been postulated to be involved in the pathophysiology in schizophrenia. To further investigate the association between MYO5B polymorphisms and schizophrenia, we genotyped nine single nucleotide polymorphisms (SNPs) in an independent sample of 1463 individuals with schizophrenia and 1563 healthy control subjects, and detected three SNPs and two haplotype blocks which displayed significant association with schizophrenia. This association was further strengthened by the results of meta-analysis. Our data strongly supported that the MYO5B gene might be associated with schizophrenia in the Chinese Han population and they have implications for understanding the glutamate hypothesis of schizophrenia. (c) 2013 Elsevier Ireland Ltd. All rights reserved.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000319184100002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Psychiatry; SCI(E); PubMed; SSCI; 4; ARTICLE; 1-2; 13-18; 207
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/190564]
专题	心理与认知科学学院
推荐引用方式 GB/T 7714	Chen, Yaguang,Tian, Lin,Zhang, Fuquan,et al. Myosin Vb gene is associated with schizophrenia in Chinese Han population[J]. psychiatry research,2013.
APA	Chen, Yaguang.,Tian, Lin.,Zhang, Fuquan.,Liu, Chenxing.,Lu, Tianlan.,...&Yue, Weihua.(2013).Myosin Vb gene is associated with schizophrenia in Chinese Han population.psychiatry research.
MLA	Chen, Yaguang,et al."Myosin Vb gene is associated with schizophrenia in Chinese Han population".psychiatry research (2013).