Protein-interaction-network-based analysis for genome-wide association   analysis of schizophrenia in Han Chinese population

doi:10.1016/j.jpsychires.2013.11.014

CORC > 北京大学 > 心理与认知科学学院

	Protein-interaction-network-based analysis for genome-wide association analysis of schizophrenia in Han Chinese population
	Yu, Hao ; Bi, Wenjian ; Liu, Chenxing ; Zhao, Yanlong ; Zhang, Ji-Feng ; Zhang, Dai ; Yue, Weihua
刊名	journal of psychiatric research
	2014
关键词	Schizophrenia Genome-wide association study Protein-interaction-network-based analysis Susceptibility gene Pathway Network COMMON VARIANTS MISSING HERITABILITY BIPOLAR DISORDER CONFERRING RISK PATHWAYS DISEASES DIFFERENTIATION LOCI
DOI	10.1016/j.jpsychires.2013.11.014
英文摘要	Schizophrenia is a severe neuropsychiatric disorder with a strong and complex genetic background. Recent genome-wide association studies (GWAS) have successfully identified several susceptibility loci of schizophrenia. In order to interpret the functional role of the genetic variants and detect the combined effects of some of these genes on schizophrenia, protein-interaction-network-based analysis (PINBA) has emerged as an effective approach. In the current study, we conducted a PINBA of our previous GWAS data taken from the Han Chinese population. In order to do so, we used dense module search (DMS), a method that locates densely connected modules for complex diseases by integrating the association signal from GWAS datasets into the human protein protein interaction (PPI) network. As a result, we identified one gene set with a joint effect significantly associated with schizophrenia and gene expression profiling analysis suggested that they were mainly neuro- and immune-related genes, such as glutamatergic gene (GRM5), GABAergic genes (GABRB1, GABARAP) and genes located in the MHC region (HLA-C, TAP2, HIST1H1B). Further pathway enrichment analysis suggested that these genes are involved in processes related to neuronal and immune systems, such as the Adherens junction pathway, the Neurotrophin signaling pathway and the Toll-like receptor signaling pathway. In our study, we identified a set of susceptibility genes that had been missed in single-marker GWAS, and our findings could promote the study of the genetic mechanisms in schizophrenia. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved.; Psychiatry; SCI(E); PubMed; SSCI; 4; ARTICLE; daizhang@bjmu.edu.cn; dryue@bjmu.edu.cn; 73-78; 50
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/190062]
专题	心理与认知科学学院
推荐引用方式 GB/T 7714	Yu, Hao,Bi, Wenjian,Liu, Chenxing,et al. Protein-interaction-network-based analysis for genome-wide association analysis of schizophrenia in Han Chinese population[J]. journal of psychiatric research,2014.
APA	Yu, Hao.,Bi, Wenjian.,Liu, Chenxing.,Zhao, Yanlong.,Zhang, Ji-Feng.,...&Yue, Weihua.(2014).Protein-interaction-network-based analysis for genome-wide association analysis of schizophrenia in Han Chinese population.journal of psychiatric research.
MLA	Yu, Hao,et al."Protein-interaction-network-based analysis for genome-wide association analysis of schizophrenia in Han Chinese population".journal of psychiatric research (2014).