TRPV1 channel-mediated bilateral allodynia induced by unilateral   masseter muscle inflammation in rats

doi:10.1186/1744-8069-9-68

CORC > 北京大学 > 心理与认知科学学院

	TRPV1 channel-mediated bilateral allodynia induced by unilateral masseter muscle inflammation in rats
	Simonic-Kocijan, Suncana ; Zhao, Xuehong ; Liu, Wen ; Wu, Yuwei ; Uhac, Ivone ; Wang, KeWei
刊名	molecular pain
	2013
关键词	Hippocampus Masseter muscle TMD TRG TRPV1 TEMPOROMANDIBULAR DISORDERS MECHANICAL ALLODYNIA TISSUE INFLAMMATION NOXIOUS-STIMULATION TRANSITION ZONE OROFACIAL DEEP PAIN HYPERALGESIA ACTIVATION EXPRESSION
DOI	10.1186/1744-8069-9-68
英文摘要	Pain in masticatory muscles is among the most prominent symptoms of temperomandibular disorders (TMDs) that have diverse and complex etiology. A common complaint of TMD is that unilateral pain of craniofacial muscle can cause a widespread of bilateral pain sensation, although the underlying mechanism remains unknown. To investigate whether unilateral inflammation of masseter muscle can cause a bilateral allodynia, we generated masseter muscle inflammation induced by unilateral injection of complete Freund's adjuvant (CFA) in rats, and measured the bilateral head withdrawal threshold at different time points using a von Frey anesthesiometer. After behavioral assessment, both right and left trigeminal ganglia (TRG) were dissected and examined for histopathology and transient receptor potential vanilloid 1 (TRPV1) mRNA expression using quantitative real-time PCR analysis. A significant increase in TRPV1 mRNA expression occurred in TRG ipsilateral to CFA injected masseter muscle, whereas no significant alteration in TRPV1 occurred in the contralateral TRG. Interestingly, central injection of TRPV1 antagonist 5-iodoresiniferatoxin into the hippocampus significantly attenuated the head withdrawal response of both CFA injected and non-CFA injected contralateral masseter muscle. Our findings show that unilateral inflammation of masseter muscle is capable of inducing bilateral allodynia in rats. Upregulation of TRPV1 at the TRG level is due to nociception caused by inflammation, whereas contralateral nocifensive behavior in masticatory muscle nociception is likely mediated by central TRPV1, pointing to the involvement of altered information processing in higher centers.; Neurosciences; SCI(E); PubMed; 3; ARTICLE; 68; 9
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/190032]
专题	心理与认知科学学院
推荐引用方式 GB/T 7714	Simonic-Kocijan, Suncana,Zhao, Xuehong,Liu, Wen,et al. TRPV1 channel-mediated bilateral allodynia induced by unilateral masseter muscle inflammation in rats[J]. molecular pain,2013.
APA	Simonic-Kocijan, Suncana,Zhao, Xuehong,Liu, Wen,Wu, Yuwei,Uhac, Ivone,&Wang, KeWei.(2013).TRPV1 channel-mediated bilateral allodynia induced by unilateral masseter muscle inflammation in rats.molecular pain.
MLA	Simonic-Kocijan, Suncana,et al."TRPV1 channel-mediated bilateral allodynia induced by unilateral masseter muscle inflammation in rats".molecular pain (2013).