Aging interferes central control mechanism for eccentric muscle   contraction

doi:10.3389/fnagi.2014.00086

CORC > 北京大学 > 心理与认知科学学院

	Aging interferes central control mechanism for eccentric muscle contraction
	Yao, Wan X. ; Li, Jinqi ; Jiang, Zhiguo ; Gao, Jia-Hong ; Franklin, Crystal G. ; Huang, Yufei ; Lancaster, Jack L. ; Yue, Guang H.
刊名	frontiers in aging neuroscience
	2014
关键词	brain activation concentric contraction eccentric contraction fMRI movement stability HUMAN MOTOR UNITS LENGTHENING CONTRACTIONS OLD ADULTS ACTIVATION PATTERNS BRAIN ACTIVATION H-REFLEX STEADINESS MOVEMENTS CORTEX AREAS
DOI	10.3389/fnagi.2014.00086
英文摘要	Previous studies report greater activation in the cortical motor network in controlling eccentric contraction (EC) than concentric contraction (CC) despite lower muscle activation level associated with EC vs. CC in healthy, young individuals. It is unknown, however, whether elderly people exhibiting increased difficulties in performing EC than CC possess this unique cortical control mechanism for EC movements. To address this question, we examined functional magnetic resonance imaging (fMRI) data acquired during EC and CC of the first dorsal interosseous (FDI) muscle in 11 young (20-32 years) and 9 old (67-73 years) individuals. During the fMR1 experiment, all subjects performed 20 CC and 20 EC of the right FDI with the same angular distance and velocity. The major findings from the behavioral and fMR1 data analysis were that (1) movement stability was poorer in EC than CC in the old but not the young group; (2) similar to previous electrophysiological and fMR1 reports, the EC resulted in significantly stronger activation in the motor control network consisting of primary, secondary and association motor cortices than CC in the young and old groups; (3) the biased stronger activation towards EC was significantly greater in the old than the young group especially in the secondary and association cortices such as supplementary and premotor motor areas and anterior cingulate cortex; and (4) in the primary motor and sensory cortices, the biased activation towards EC was significantly greater in the young than the old group. Greater activation in higher-order cortical fields for controlling EC movement by elderly adults may reflect activities in these regions to compensate for agingrelated impairments in the ability to control complex EC movements. Our finding is useful for potentially guiding the development of targeted therapies to counteract age-related movement deficits and to prevent injury.; Geriatrics & Gerontology; Neurosciences; SCI(E); PubMed; 2; ARTICLE; wanxiang.yao@utsa.edu; gyue@kesslerfounation.org; 86; 6
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/189036]
专题	心理与认知科学学院
推荐引用方式 GB/T 7714	Yao, Wan X.,Li, Jinqi,Jiang, Zhiguo,et al. Aging interferes central control mechanism for eccentric muscle contraction[J]. frontiers in aging neuroscience,2014.
APA	Yao, Wan X..,Li, Jinqi.,Jiang, Zhiguo.,Gao, Jia-Hong.,Franklin, Crystal G..,...&Yue, Guang H..(2014).Aging interferes central control mechanism for eccentric muscle contraction.frontiers in aging neuroscience.
MLA	Yao, Wan X.,et al."Aging interferes central control mechanism for eccentric muscle contraction".frontiers in aging neuroscience (2014).