Peri-adolescence isolation rearing alters social behavior and   nociception in rats

doi:10.1016/j.neulet.2010.05.067

CORC > 北京大学 > 心理与认知科学学院

	Peri-adolescence isolation rearing alters social behavior and nociception in rats
	Meng, Qingxuan ; Li, Nanxin ; Han, Xiao ; Shao, Feng ; Wang, Weiwen
刊名	神经科学快报
	2010
关键词	Adolescent Anxiety Open field Pain sensitivity Social interaction Social isolation ISOLATION-REARED RATS DEFENSIVE BURYING BEHAVIOR PREPULSE INHIBITION PAIN SENSITIVITY GENE-EXPRESSION ADULT RATS SCHIZOPHRENIA DEPRIVATION DEFICITS MORPHINE
DOI	10.1016/j.neulet.2010.05.067
英文摘要	Social isolation results in fundamental behavioral abnormalities in rodents which models certain neuropsychiatric disorders such as schizophrenia. However, the developmental stage that is most vulnerable to social isolation is largely unknown. In the present study, we subjected weaning rats to a four-week peri-adolescence isolation rearing (PAIR) and then returned them to social rearing for an additional four weeks until adulthood. Open field locomotion, social interaction behavior, and acute pain sensitivity were examined at different time points. PAIR rats showed moderate hyperactivity towards a novel environment, an anxiogenic-like behavioral profile, and increased aggression and social interaction behavior, the last three of which could be restored by re-socialization procedure. In addition, PAIR animals showed significantly reduced pain sensitivity even after the re-socialization period. In summary, this study advances the use of pen-adolescent isolation rearing as an animal model to study neurodevelopmental manipulation induced behavioral abnormalities. (C) 2010 Elsevier Ireland Ltd. All rights reserved.; Neurosciences; SCI(E); PubMed; 25; ARTICLE; 1; 25-29; 480
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/162841]
专题	心理与认知科学学院
推荐引用方式 GB/T 7714	Meng, Qingxuan,Li, Nanxin,Han, Xiao,et al. Peri-adolescence isolation rearing alters social behavior and nociception in rats[J]. 神经科学快报,2010.
APA	Meng, Qingxuan,Li, Nanxin,Han, Xiao,Shao, Feng,&Wang, Weiwen.(2010).Peri-adolescence isolation rearing alters social behavior and nociception in rats.神经科学快报.
MLA	Meng, Qingxuan,et al."Peri-adolescence isolation rearing alters social behavior and nociception in rats".神经科学快报 (2010).