Cognitive, emotional and neurochemical effects of repeated maternal   separation in adolescent rats

doi:10.1016/j.brainres.2013.04.026

CORC > 北京大学 > 心理与认知科学学院

	Cognitive, emotional and neurochemical effects of repeated maternal separation in adolescent rats
	Li, Man ; Xue, Xiaofang ; Shao, Shuang ; Shao, Feng ; Wang, Weiwen
刊名	脑研究
	2013
关键词	Maternal separation Prepulse inhibition Anxiety Dopamine D2 receptor 5-HT1A receptor Prefrontal cortex Nucleus accumbens Hippocampus MEDIAL PREFRONTAL CORTEX CHRONIC CANNABINOID TREATMENT STRESSFUL LIFE EVENT ADULT RATS PREPULSE INHIBITION NUCLEUS-ACCUMBENS LATENT INHIBITION ACOUSTIC STARTLE SOCIAL-ISOLATION ANIMAL-MODELS
DOI	10.1016/j.brainres.2013.04.026
英文摘要	As an adverse early life experience, maternal separation (MS) induces profound neurochemical, cognitive and emotional dysfunction. Previous studies have reported that MS affected prepulse inhibition (PPI), anxiety-related behaviors, dopaminergic and serotonergic activity in adult rats, and in the present study, we investigated the effects of repeated (4 h/day) maternal separation during postnatal days 1-21 on PPI and anxiety-related behaviors in an elevated plus maze, as well as dopamine D2 receptor (DRD2) and 5-HT1A receptor expression in the medial prefrontal cortex (mPFC), nucleus accumbens (NAc) and hippocampus in adolescent rats. Our findings show that repeated MS results in reduced PPI, increased anxiety-related behaviors, decreased DRD2 protein expression in the NAc and hippocampus, and decreased 5-HT1A protein expression in the mPFC and hippocampus in adolescent rats. These data further demonstrate that MS can be used as an animal model of neuropsychiatric disease. (c) 2013 Elsevier B.V. All rights reserved.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000321082900008&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Neurosciences; SCI(E); PubMed; 21; ARTICLE; 82-90; 1518
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/162777]
专题	心理与认知科学学院
推荐引用方式 GB/T 7714	Li, Man,Xue, Xiaofang,Shao, Shuang,et al. Cognitive, emotional and neurochemical effects of repeated maternal separation in adolescent rats[J]. 脑研究,2013.
APA	Li, Man,Xue, Xiaofang,Shao, Shuang,Shao, Feng,&Wang, Weiwen.(2013).Cognitive, emotional and neurochemical effects of repeated maternal separation in adolescent rats.脑研究.
MLA	Li, Man,et al."Cognitive, emotional and neurochemical effects of repeated maternal separation in adolescent rats".脑研究 (2013).