Serotonin receptor gene (5-HT1A) modulates alexithymic characteristics   and attachment orientation

doi:10.1016/j.psyneuen.2014.09.001

CORC > 北京大学 > 心理与认知科学学院

	Serotonin receptor gene (5-HT1A) modulates alexithymic characteristics and attachment orientation
	Gong, Pingyuan ; Liu, Jinting ; Li, She ; Zhou, Xiaolin
刊名	psychoneuroendocrinology
	2014
关键词	Alexithymia Attachment Serotonin Genetic polymorphism 5-HT1A ADULT ATTACHMENT MAJOR DEPRESSION TRANSPORTER GENE PROMOTER POLYMORPHISM PERSONALITY-DISORDER CHINESE POPULATION STYLE BRAIN 5-HTTLPR SUSCEPTIBILITY
DOI	10.1016/j.psyneuen.2014.09.001
英文摘要	Previous studies have indicated that alexithymia is associated with the availability of serotonin in the brain and with the insecure attachment orientation. Inspired by the finding that the receptor 5-HT1A modulates the level of serotonin in the brain, this study investigated to what extent a polymorphism (C-1019G, rs6295) of 5-HT1A gene modulates individuals' alexithymic characteristics and attachment orientation in 504 Chinese Han people. Results showed significantly higher total scores on the 20-item Toronto Alexithymia Scale (TAS-20) for individuals carrying the CG/GG genotype than for individuals carrying the CC genotype. Specifically, individuals with the CG/GG genotype reported greater difficulty in identifying own feelings than individuals with the CC genotype. Results also showed that individuals carrying the CG/GG genotype seemed to be less comfortable with having close relationships to others than individuals with the CC genotype. These findings provide the first evidence for the link between 5-HT1A and the development of alexithymic characteristics and attachment orientation. (C) 2014 Elsevier Ltd. All rights reserved.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000345061000026&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Endocrinology & Metabolism; Neurosciences; Psychiatry; SCI(E); PubMed; 3; ARTICLE; xz104@pku.edu.cn; 274-279; 50
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/162735]
专题	心理与认知科学学院
推荐引用方式 GB/T 7714	Gong, Pingyuan,Liu, Jinting,Li, She,et al. Serotonin receptor gene (5-HT1A) modulates alexithymic characteristics and attachment orientation[J]. psychoneuroendocrinology,2014.
APA	Gong, Pingyuan,Liu, Jinting,Li, She,&Zhou, Xiaolin.(2014).Serotonin receptor gene (5-HT1A) modulates alexithymic characteristics and attachment orientation.psychoneuroendocrinology.
MLA	Gong, Pingyuan,et al."Serotonin receptor gene (5-HT1A) modulates alexithymic characteristics and attachment orientation".psychoneuroendocrinology (2014).