Families of Nuclear Receptors in Vertebrate Models: Characteristic and   Comparative Toxicological Perspective

doi:10.1038/srep08554

CORC > 北京大学 > 城市与环境学院

	Families of Nuclear Receptors in Vertebrate Models: Characteristic and Comparative Toxicological Perspective
	Zhao, Yanbin ; Zhang, Kun ; Giesy, John P. ; Hu, Jianying
刊名	scientific reports
	2015
关键词	LIGAND-BINDING DOMAIN 9-CIS RETINOIC ACID X RECEPTOR ZEBRAFISH
DOI	10.1038/srep08554
英文摘要	Various synthetic chemicals are ligands for nuclear receptors (NRs) and can cause adverse effects in vertebrates mediated by NRs. While several model vertebrates, such as mouse, chicken, western clawed frog and zebrafish, are widely used in toxicity testing, few NRs have been well described for most of these classes. In this report, NRs in genomes of 12 vertebrates are characterized via bioinformatics approaches. Although numbers of NRs varied among species, with 40-42 genes in birds to 66-74 genes in teleost fishes, all NRs had clear homologs in human and could be categorized into seven subfamilies defined as NR0B-NR6A. Phylogenetic analysis revealed conservative evolutionary relationships for most NRs, which were consistent with traditional morphology-based systematics, except for some exceptions in Dolphin (Tursiops truncatus). Evolution of PXR and CAR exhibited unexpected multiple patterns and the existence of CAR possibly being traced back to ancient lobe-finned fishes and tetrapods (Sarcopterygii). Compared to the more conservative DBD of NRs, sequences of LBD were less conserved: Sequences of THRs, RARs and RXRs were >= 90% similar to those of the human, ERs, AR, GR, ERRs and PPARs were more variable with similarities of 60%-100% and PXR, CAR, DAX1 and SHP were least conserved among species.; Multidisciplinary Sciences; SCI(E); PubMed; 0; ARTICLE; zhaoyb@pku.edu.cn; hujy@urban.pku.edu.cn; 8554; 5
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/322079]
专题	城市与环境学院
推荐引用方式 GB/T 7714	Zhao, Yanbin,Zhang, Kun,Giesy, John P.,et al. Families of Nuclear Receptors in Vertebrate Models: Characteristic and Comparative Toxicological Perspective[J]. scientific reports,2015.
APA	Zhao, Yanbin,Zhang, Kun,Giesy, John P.,&Hu, Jianying.(2015).Families of Nuclear Receptors in Vertebrate Models: Characteristic and Comparative Toxicological Perspective.scientific reports.
MLA	Zhao, Yanbin,et al."Families of Nuclear Receptors in Vertebrate Models: Characteristic and Comparative Toxicological Perspective".scientific reports (2015).