Simultaneous determination of tetracyclines and their degradation   products in environmental waters by liquid chromatography-electrospray   tandem mass spectrometry

doi:10.1016/j.chroma.2009.03.073

CORC > 北京大学 > 城市与环境学院

	Simultaneous determination of tetracyclines and their degradation products in environmental waters by liquid chromatography-electrospray tandem mass spectrometry
	Jia, Ai ; Xiao, Yang ; Hu, Jianying ; Asami, Mari ; Kunikane, Shoichi
刊名	journal of chromatography a
	2009
关键词	Tetracyclines Tetracycline degradation products Environmental analysis MAX cartridge cleanup LC-ESI-MS/MS SOLID-PHASE EXTRACTION LC-MS-MS WASTE-WATER RESISTANCE GENES SURFACE-WATER SULFONAMIDE ANTIBIOTICS ESCHERICHIA-COLI OXYTETRACYCLINE PHARMACEUTICALS RIVER
DOI	10.1016/j.chroma.2009.03.073
英文摘要	A sensitive method was developed for the trace determination of six tetracyclines and ten of their degradation products in influent, effluent, and river waters using liquid chromatography-electrospray tandem mass spectrometry detection, combined with Oasis hydrophilic-lipophilic balance (HLB) cartridge extraction and Oasis mixed-mode strong anion exchange (MAX) cartridge cleanup. Tetracyclines and their products were separated by liquid chromatography in 9.5 min, and the instrument detection limits were generally between 0.03 and 0.1 mu g/L except for minocycline (0.5 mu g/L). The chromatograms were improved through the MAX cleanup and no apparent matrix effect was found. The recoveries of all the target compounds except for 4-epianhydrochlortetracycline and anhydrochlortetracycline (34-52%) were 75-120% for influent, 61-103% for effluent, and 64-113% for river waters. The method detection limits (MDLs) of the analytes varied in the range of 0.8-17.5 ng/L in all studied matrices. The method was applied for the determination of tetracyclines and their products in a sewage treatment plant (STP) and Surface waters in Beijing, China. Oxytetracycline (3.8-72.5 ng/L), tetracycline (1.9-16.5 ng/L). and five products including 4-epitetracycline, 4-epioxytetracycline, isochlortetracycline, anhydrotetracycline, and 4-epianhydrochlortetracycline (5.7-25.3 ng/L) were detected in wastewater, while only oxytetracycline and tetracycline (2.2 and 2.1 ng/L) were detected in surface water samples. Crown Copyright (C) 2009 Published by Elsevier B.V. All rights reserved.; Biochemical Research Methods; Chemistry, Analytical; SCI(E); EI; PubMed; 41; ARTICLE; 22; 4655-4662; 1216
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/160742]
专题	城市与环境学院
推荐引用方式 GB/T 7714	Jia, Ai,Xiao, Yang,Hu, Jianying,et al. Simultaneous determination of tetracyclines and their degradation products in environmental waters by liquid chromatography-electrospray tandem mass spectrometry[J]. journal of chromatography a,2009.
APA	Jia, Ai,Xiao, Yang,Hu, Jianying,Asami, Mari,&Kunikane, Shoichi.(2009).Simultaneous determination of tetracyclines and their degradation products in environmental waters by liquid chromatography-electrospray tandem mass spectrometry.journal of chromatography a.
MLA	Jia, Ai,et al."Simultaneous determination of tetracyclines and their degradation products in environmental waters by liquid chromatography-electrospray tandem mass spectrometry".journal of chromatography a (2009).